Results 171 to 180 of about 220,602 (307)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Explainable multi-modal deep learning for transparent cancer diagnosis: integrating radiology, clinical features, and decision visualization. [PDF]

Front Artif Intell
Dash S, Bewoor L, Dongre Y, Bhosle A, Patil K, Jadhav S, Mohapatra B, Walia B.   +7 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Explainable and uncertainty-aware ensemble framework with causal analysis for breast cancer detection. [PDF]

Front Oncol
Zaheer Sajid M, Fareed Hamid M, Qureshi I.   +2 more
europepmc   +1 more source

Analysis of Molecular Variance (AMOVA) depicting the percentage of variation explained among groups (Moncul River, Queule River, Lingue River, Valdivia River, Chaihuín River, Maullín River, and Magellanic Province populations), among populations within groups, and within populations.

, 2015
Claudio A. González‐Wevar, Pilar Salinas, Mathias Hüne, Nicolás I. Segovia, Luis Vargas‐Chacoff, Marcela Astorga, Juan I. Cañete, Élie Poulin   +7 more
openalex   +2 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Explainable AI-Driven Quality and Condition Monitoring in Smart Manufacturing. [PDF]

Sensors (Basel)
Ahangar MN, Farhat ZA, Sivanathan A, Ketheesram N, Kaur S.   +4 more
europepmc   +1 more source

Explaining robust additive utility models by sequences of preference swaps

, 2015
Khaled Belahcène, Christophe Labreuche, Nicolas Maudet, Vincent Mousseau, Wassila Ouerdane   +4 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Explainable artificial intelligence in air traffic control: effects of expertise on workload, acceptance, and usage intentions. [PDF]

Brain Inform
Cartocci G, Veyrié A, Cavagnetto N, Hurter C, Degas A, Ferreira A, Ahmed MU, Begum S, Barua S, Inguscio BMS, Ronca V, Borghini G, Di Flumeri G, Babiloni F, Aricò P.   +14 more
europepmc   +1 more source