Results 91 to 100 of about 66,453 (258)

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

In situ fiber-optical monitoring of cytosolic calcium in tissue explant cultures

, 2013
We present a fluorescence-lifetime based method for monitoring cell and tissue activity in situ, during cell culturing and in the presence of a strong autofluorescence background.
Martin Frenz, Geiser, Marianne, Manuel Ryser, Jaro Rička, Lisa Künzi, Marianne Geiser, Ryser, Manuel, Künzi, Lisa, Frenz, Martin, Ricka, Jaro   +9 more
core   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Evaluation of In vitro Embryo Culture and the Effect of Medium Culture, Hormone Levels and Explant Types on Callus Induction and Shoot Organogenesis of Ferula gummosa B.

Journal of Medicinal Plants, 2008
Background: Gummosa (Ferula gummosa B.) is a highly valuable medicinal plant belonging to the Apiaceae family. it is a herbaceous, perennial and monocarpic plant. Flowers appear only once during the life cycle of the plant.
R Sarabadani, M Omidi, M Bihamta, S Davazdah emami   +3 more
doaj  

Effect of explant type on the rooting and acclimatization of Dianthus serotinus Waldst. & Kit. [PDF]

, 2014
The effect of the concentration of MS salts and explant type on D. serotinus rooting and acclimatization was investigated in order to optimize a protocol for the micropropagation of this species.
Marković Marija, Grbić Mihailo, Skočajić Dragana, Đukić Matilda   +3 more
core   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Adipose tissue explant culture using PDMS flow chambers: an alternative to static explant culture

Adipocyte
As obesity rates continue to rise, it is important that we can effectively study adipose tissue to understand its physiological contribution in individuals with obesity.
M Cohen, P Bandaru, K Szylo, N Nguyen, B Nadeak, R Paszkiewicz, JW Ashby, JJ Mack, L Tanaka, J Tan, A Khademhosseini, SD Mittelman   +11 more
doaj   +1 more source

In vitro–ex vivo correlations between a cell-laden hydrogel and mucosal tissue for screening composite delivery systems

Drug Delivery, 2017
Composite delivery systems where drugs are electrospun in different layers and vary the drug stacking-order are posited to affect bioavailability. We evaluated how the formulation characteristics of both burst- and sustained-release electrospun fibers ...
Anna K. Blakney, Adam B. Little, Yonghou Jiang, Kim A. Woodrow   +3 more
doaj   +1 more source

Multilineage differentiation potential of bone and cartilage cells derived from explant culture [PDF]

, 2009
To date, mesenchymal stem cells (MSCs) from various tissues have been reported, but the yield and differentiation potential of different tissue-derived MSCs is still not clear. This study was undertaken in an attempt to investigate the multilineage stem
Xiao, Yin, Yameen, Zareen, Leavesley, David, Upton, Zee   +3 more
core  

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source