Results 171 to 180 of about 2,325,301 (352)
Current Issues in Education, 2014 Appropriate views of the nature of science are vital to scientific literacy yet rarely taught in US schools primarily due to naïve NOS views held by teachers. Thus, most school teachers need further educational NOS experiences and instruction.
Andrea Rae Milner +2 more
doaj
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Developing pragmatic awareness of suggestions in the EFL classroom: A focus on instructional effects
Canadian Journal of Applied Linguistics, 2007 The role of instruction to develop learners’ pragmatic competence in both second and foreign language contexts has recently motivated a great deal of research.
Alicia Martínez-Flor, Eva Alcón Soler
doaj
SAGE OpenThis study aims to investigate the effectiveness of explicit information (EI) in the context of Processing Instruction (PI) as an alternative to traditional teaching methods. PI encompasses explicit information and structured input activity (SI). However,
Tao Zeng, Peng Xu, Xi Gao
doaj +1 more source
Assessing Vocabulary of Children: Investigating the Evaluation and Instruction of Basic Concepts [PDF]
, 2015 Vocabulary knowledge of preschool children is a key factor in predicting literacy success in elementary school (Hammer, Farkas, & Maczuga, 2010). However, few deliberate attempts to teach basic concept vocabulary have been studied (Bowers & Schwarz, 2013;
Smith, Rebecca Elizabeth
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Instruction of Metacognitive Strategies to Enhance Students’ Listening Comprehension
Asian Journal of Assessment in Teaching and Learning, 2013 The listening skill has been reported as a neglected skill in the ESL classroom. The lack of attention to this particular skill has been linked to ESL students’ poor performance in authentic communication and examinations.
Latha K. Krishnan, Napisah Kepol
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source