Results 201 to 210 of about 485,070 (308)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Neurodevelopmental correlates of emotion regulation in adolescence: An accelerated longitudinal study. [PDF]

Dev Cogn Neurosci
Karpov G, Heyn SA, Russell JD, Keding TJ, Herringa RJ.   +4 more
europepmc   +1 more source

A place for explicit phonological instruction

A place for explicit phonological instruction
For most learners, acquiring native-like competence in a foreign language is a difficult task. There is a vast literature on language acquisition, first language acquisition and second language acquisition, and among those factors which will have a bearing on success we may wish to include first language, age, experience, aptitude, motivation, attitude,
openaire  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

A scoping review of EFL learners' interlanguage pragmatic development. [PDF]

PLoS One
Li H, Kasim ZM, Ang LH.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Explicit tier two vocabulary instruction for young deaf children. [PDF]

J Deaf Stud Deaf Educ
Klieve S, Leigh K, Grant L, Graham L.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effects of attentional instructions on neural and behavioral correlates of vocal auditory feedback control in post-stroke aphasia. [PDF]

Neuroimage
Zhang Y, Behroozmand R.
europepmc   +1 more source

Explicit Phoneme Instruction : A Classroom Study

Explicit Phoneme Instruction : A Classroom Study
This article reports on a classroom listening study. This study tested the success of lab-based studies that improved the acquisition of difficult nonnative phonemic categories. Two research questions were asked: 1) To what extent can the success of lab-based perceptual training studies be replicated in an EFL classroom?
openaire