Results 111 to 120 of about 446,243 (313)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Exploitation, inequality, and power

open access: yes
The concept of exploitation is central in social and political theory, but there is no precise, widely accepted definition. This paper analyses John Roemer’s seminal theory, which construes exploitation as a distributive injustice arising from asset ...
Veneziani, Roberto
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Exploitation of Labour and Exploitation of Commodities: a “New Interpretation”

open access: yes
In the standard Okishio-Morishima approach, the existence of profits is proved to be equivalent to the exploitation of labour. Yet, it can also be proved that the existence of profits is equivalent to the ‘exploitation’ of any good.
Yoshihara, Naoki, Veneziani, Roberto
core  

Dispatcher3 D7.2 - Project communication, dissemination and exploitation rreport

open access: yes, 2022
This deliverable presents a report of the communication, dissemination and exploitation activities carried out by the Dispatcher3 consortium during the course of the project.
Delgado, L.   +3 more
core  

Dispatcher3 D7.1 - Project communication, dissemination and exploitation plan [PDF]

open access: yes, 2020
This document is the Communication, Dissemination and Exploitation Plan (D7.1) of the Clean Sky 2 Innovation Action Dispatcher3. The document defines the communication and dissemination actions to be performed during the project, and the potential ...
De Falco, P.   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Preventing Trafficking for Labour Exploitation

open access: yes, 2014
Experts in the field of human trafficking place central importance on the 'three Ps' first set out in the UN Human Trafficking Protocol (2003) as an effective framework for combating this global problem: prevention, protection and prosecution.
Caroline Robinson
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Exploration and exploitation strategies. What kind of analytical models ? [PDF]

open access: yes
This paper gives some insights related to the combination of exploration and exploitation behaviors. A recurrent question for firms deals with this blend of exploration and exploitation mechanisms. Firms are engaged in new activities like research and at
Nadia Jacoby
core  

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