Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Dynamics of Spatial Exploitation: A Metapopulation Approach [PDF]
We present a bioeconomic model of a harvesting industry operating over a heterogeneous environment comprised of discrete biological populations interconnected by dispersal processes. The model generalizes the H. S. Gordon [1954]/V.
Sanchirico, James, Wilen, James
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How Uncertainty Affects Children's Exploration and Exploitation in Statistical Learning. [PDF]
Dev SciTong SX, Zhang P, Zhou M, Ziegler JC.
europepmc +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
A Q-Learning-Enhanced Cuckoo Catfish Optimizer (CCO-RL): A Comparative Study of Nine Metaheuristics Applied to CEC2017, CEC2022 and Engineering Design Problems. [PDF]
Biomimetics (Basel)Tawil AA +3 more
europepmc +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
'The evils are uncontrolled': Marx's Capital as a form of witnessing for child public health. [PDF]
J Public Health (Oxf)Balfe M.
europepmc +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
RESOURCE EXPLOITATION, BIODIVERSITY LOSS AND ECOLOGICAL EVENTS
We study the management of a natural resource that supports ecosystems as well as human needs. The reduction in the resource base introduces a threat of occurrence of catastrophic ecological events, such as the sudden collapse of the national habitat ...
Tsur, Yacov, Zemel, Amos
core