Results 131 to 140 of about 7,177,335 (349)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Preparing a microemulsion-loaded hydrogel for cleaning wall paintings and coins

Heritage Science
Removing unwanted materials, such as organic coatings and soil, from the cultural relic surface is a complex and significant task in the field of cultural heritage conservation.
Jinmeng Zhu, Jiapeng Wang, Jia Wang, Jinghan Ding, Xichen Zhao, Wenqiang Dong, Zhiyong Lu, Xuanhua Li   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Poetry as a site of history education and exploration: learning history from and with poetry

History Education Research Journal
Poetry has, historically and currently, been used to express resistance against hegemonic powers and power abuses. Poems have the potential to be both historical sources and personal comments on history, containing historical content and framing this ...
doaj   +2 more sources

Low thermal inertia of carbonaceous asteroid Bennu driven by cracks observed in returned samples

Nature Communications
Thermal inertia is used to infer physical properties of asteroid surfaces. The carbonaceous asteroid Bennu has low thermal inertia suggestive of a surface covered in sub-centimeter rock fragments.
A. J. Ryan, R.-L. Ballouz, R. J. Macke, T. Ishizaki, A. Alasli, J. Biele, S. A. Eckley, C. G. Hoover, K. Jardine, A. J. King, C. P. Opeil, M. Pajola, F. Tusberti, J. J. Barnes, H. C. Bates, E. L. Berger, E. B. Bierhaus, C. Calva, S. Cambioni, F. Cheng, M. Delbo, D. N. DellaGiustina, J. P. Dworkin, C. M. Elder, J. P. Emery, J. Freemantle, R. Fujita, D. P. Glavin, C. Gonzalez, P. Haenecour, V. E. Hamilton, R. D. Hanna, L. T. J. Hanton, R. Harrington, A. R. Hildebrand, D. H. Hill, K. Ishimaru, E. R. Jawin, M. K. Kontogiannis, N. G. Lunning, T. J. McCoy, J. L. Molaro, M. Montoya, H. Nagano, E. W. O’Neal, J. Plummer, K. Righter, N. Sakatani, P. Sánchez, P. F. Schofield, M. A. Siegler, S. Tanaka, T. J. Zega, C. W. V. Wolner, H. C. Connolly, D. S. Lauretta   +55 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The 1990 update to strategy for exploration of the inner planets [PDF]

The Committee on Planetary and Lunar Exploration (COMPLEX) has undertaken to review and revise the 1978 report Strategy for Exploration of the Inner Planets, 1977-1987. The committee has found the 1978 report to be generally still pertinent.
Cheng, Andrew F., Esposito, Larry W., Jakosky, Bruce M., Lunine, Jonathan I., Mcfadden, Lucy-Ann, Mckay, Christopher P., Mckinnon, William B., Muhleman, Duane O., Nicholson, Philip, Pepin, Robert O.   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Goodby Columbus and all that: history and textual criticism

NWIG, 1993
[First paragraph] Columbus. FELIPE FERNANDEZ-ARMESTO. Oxford: Oxford University Press, 1991. xxvii + 218 pp. (Cloth US$ 16.95, Paper US$ 6.99) The Worlds of Christopher Columbus. WILLIAM D. PHILLIPS, JR. & CARLA RAHN PHILLIPS.
Teofilo F. Ruiz
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