Results 121 to 130 of about 71,949 (309)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Users as inventors and developers of radical innovation: An explorative case study analysis in the field of medical technology [PDF]
Our study focuses on the question, whether users should be intensively involved in the innovation process of radical product innovations or better not - from the manufacturer's perspective.
Herstatt, Cornelius, Lettl, Christopher
core
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Global Strategy and the Acquisition of Local Knowledge How MNCs Enter Regional Knowledge Clusters [PDF]
The paper addresses two recent interrelated phenomena: High- tech regional knowledge clusters, and globalization of R&D activities by multinational corporations (MNCs).
Mark Lorenzen, Volker Mahnke
core
The Effects of Integrative Capability on Explorative Innovation and Exploitative Innovation [PDF]
, 2016 经济全球化背景下，环境变化加快，市场风险加剧。企业为巩固市场地位，开拓市场领域，选择与其他企业构建战略联盟。企业间通过获取应用外部资源和惯例，可以解决内部资源和惯例的竞争压力，协调企业同步进行探索性创新和应用性创新。应用性创新可以帮助企业从现有市场快速获取利润，探索性创新可以帮助企业从新的市场获取高额利润。然而联盟企业间的资源和惯例的匹配与协调并非自然发生，是需要合作企业有目的、有意识地培育与管理。很多联盟的失败归根到底是由于企业之间的整合不够充分。现有研究文献中 ...
林建东
core
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Key elements for promoting public-private partnerships in research and innovation
Cogent Business & ManagementPublic-private partnerships have been widely applied in financing infrastructure development with mixed results. Research calls to extend public-private partnerships to research and innovation to foster strategic linkages between research and industry ...
Shem Sikombe +5 more
doaj +1 more source