Results 101 to 110 of about 1,670,948 (272)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Critical Exploratory Data Analysis on Stroke Prediction Dataset

Jurnal Komputer Terapan
Stroke is a significant global health concern, requiring an in-depth understanding of the complex factors contributing to its occurrence. Age, body mass index (BMI), and average glucose levels are critical factors in stroke etiology.
Muhammad Arif Ariful Furqon, Nina Fadilah Najwa, Mohamad Zarkasi, Priza Pandunata, Gama Wisnu Fajariyanto   +4 more
doaj   +1 more source

The geography of French creative class: An exploratory spatial data analysis [PDF]

This paper analyses the creative class geography in France, in 2006. This geography is seen here through the lens of Explanatory Spatial Data Analysis (ESDA).
Stéphane VIROL (GREThA, UMR CNRS 5113), Stéphanie PERES (USC INRA 2032 GAIA), Sébastien CHANTELOT (ESC Bretagne Brest)   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Interactive exploratory data analysis tool in Alzheimer’s disease

Frontiers in Systems Neuroscience, 2015
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive impairment, and a variety of neuropathological changes, which are not homogenous between different brain regions within a given patient or between patients.
Diana Furcila, Juan Morales, Angel Rodriguez, Javier DeFelipe, Javier DeFelipe, Lidia Alonso-Nanclares   +5 more
doaj   +1 more source

DivBrowse-interactive visualization and exploratory data analysis of variant call matrices. [PDF]

Gigascience, 2022
König P, Beier S, Mascher M, Stein N, Lange M, Scholz U.   +5 more
europepmc   +1 more source

Geography and economic performance: exploratory spatial data analysis for Great Britain [PDF]

This paper uses the techniques of exploratory spatial data analysis to analyse patterns of spatial association for different indicators of economic performance, and in so doing identify and describe the spatial structure of economic performance for Great
Patacchini, Eleonora, Rice, Patricia
core  

French creative clusters: An exploratory spatial data analysis [PDF]

, 2010
Since Florida (2002b) revealed the importance of creative skills on economic growth, the notion of "creative class" has been deepened to analyze factors that shape the geography of talent of creative people.
Sébastien, Chantelot
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source