Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Visualising Spatio-Temporal Gaze Characteristics for Exploratory Data Analysis in Clinical Fetal Ultrasound Scans. [PDF]
Proc Eye Track Res Appl Symp, 2022 Teng C +4 more
europepmc +1 more source
, 2019 Modern grid monitoring equipment enables utilities to collect detailed records of power interruptions. These data are aggregated to compute publicly reported metrics describing high-level characteristics of grid performance. The current work explores the
Dunn, Laurel N. +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Global landscape of COVID-19 vaccination progress: insight from an exploratory data analysis. [PDF]
Hum Vaccin Immunother, 2022 Dey SK +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Exploratory Data Analysis for the Evaluation of Tribological Properties of Wear-Resistant Surface Layers Modified with Rare-Earth Metals. [PDF]
Materials (Basel), 2022 Malinowski P +3 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The evolution of the spatial and sectoral patterns in Ile-de-France over 1978-1997 [PDF]
The aim of this paper is to analyze the intra-urban spatial distribution of employment in the agglomeration of Ile-de-France in 1978 and 1997. In that purpose, exploratory spatial data analysis is used in order to identify employment centers and a ...
Céline Boiteux-Orain +2 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source