Results 171 to 180 of about 1,670,948 (272)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Geochemical exploration for tantalum in coltan-rich pegmatites at Bewadze-Mankoadze area of the Kibi-Winneba Belt, southern Ghana: Constraints from exploratory data analysis. [PDF]
HeliyonSunkari ED, Nkansah J, Adams SJ.
europepmc +1 more source
Analysing the Covid-19 Cases in Kerala: a Visual Exploratory Data Analysis Approach. [PDF]
SN Compr Clin Med, 2020 S J, Sreedharan S.
europepmc +1 more source
Current perspective of COVID-19 spread across South Korea: exploratory data analysis and containment of the pandemic. [PDF]
Environ Dev Sustain, 2021 Arora AS, Rajput H, Changotra R.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
An exploratory data analysis of word form prediction during word-by-word reading. [PDF]
Proc Natl Acad Sci U S A, 2020 Urbach TP, DeLong KA, Chan WH, Kutas M.
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Exploratory Analysis of Multivariate Data (Unsupervised Image Segmentation and Data Driven Linear and Nonlinear Decomposition) [PDF]
, 2002 Hilger, Klaus Baggesen
core +1 more source