Results 121 to 130 of about 926,701 (318)

Key elements for promoting public-private partnerships in research and innovation

Cogent Business & Management
Public-private partnerships have been widely applied in financing infrastructure development with mixed results. Research calls to extend public-private partnerships to research and innovation to foster strategic linkages between research and industry ...
Shem Sikombe, Franco Muleya, Joseph Phiri, Sambo Zulu, Peter Simasiku, Mercy Situtu   +5 more
doaj   +1 more source

A preliminary study on exploratory search behavior of undergraduate students in China

, 2012
Purpose: This study attempts to investigate how a user's search behavior changes in the exploratory search process in order to understand the characteristics of the user's search behavior and build a behavioral model.Design/methodology/approach: Forty ...
FENG Jia, Zhang Yunqiu (E-mail:yunqiu@jlu.edu.cn), ZHANG Yunqiu, AN Wenxiu   +3 more
core  

Listening Effort and Cognitive Decline: An Exploratory Study Using Pupillometry [PDF]

, 2019
For today’s ageing population, hearing loss and dementia prevalence are expected to increase. Recent research suggests that hearing loss is the highest modifiable risk factor for dementia in midlife.
Patou, François, Waldemar, Gunhild, Maier, Anja, Feldman, Alix   +3 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Influence of Including Goalkeepers on the Intensity Demands of Walking Football Practice

Sports
This preliminary study examined the effects of playing walking football with and without a goalkeeper (GK) on physiological, physical, technical, and perceptual variables in older men. Twenty participants (67 ± 4.7 years) engaged in two five vs.
Júlio A. Costa, César André Coelho, António Ferraz, João Brito, José Guilherme, André Seabra, Bruno Travassos, Hugo Folgado, Bruno Gonçalves   +8 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Improving Exploratory Search Interfaces: Adding Value or Information Overload?

, 2008
One method for supporting more exploratory forms of search has been to include a compound of new interface features, such as facets, previews, collection points, synchronous communication, and note-taking spaces, within a single search interface.
Wilson, Max L., schraefel, m.c.
core