Results 231 to 240 of about 940,336 (300)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Identification of priority practice areas for evidence-based care in congenital heart Disease: An exploratory Survey of non-medical healthcare professionals affiliated with the Italian Society of Pediatric Cardiology. [PDF]

Int J Cardiol Congenit Heart Dis
Magon A, Flocco SF, Scolari S, Conte G, Arrigoni C, Ghizzardi G, Campioni G, Nedesca RB, Gambirasi E, Di Iorio F, Orlando R, Castaldi M, Gatti C, Fazio PC, Rubin M, Pirti C, Baratta S, Carandente A, Angileri S, Caruso R.   +19 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Incidence of hair loss concerns in women who wear the hijab: an exploratory survey. [PDF]

Int J Womens Dermatol
Hasan M, Hollins LC, Helm M.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Complementary Feeding in the Clinical Practice: An Exploratory Survey among Italian Primary Care Pediatricians. [PDF]

Nutrients
Capra ME, Decarolis NM, Stanyevic B, Giudice A, Monopoli D, Neglia C, Ramundo G, Esposito S, Biasucci G, Italian Preventive and Social Pediatrics Society (SIPPS)—Emilia-Romagna Section.   +9 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Hearing and Listening Difficulties in High Schools and Universities: The Results of an Exploratory Survey of a Large Number of Students and Teachers in the Friuli-Venezia Giulia and Umbria Regions, Italy. [PDF]

Audiol Res
Gambacorta V, Stivalini D, Granieri N, Marchi R, Fabbri A, Viola P, Astorina A, Fastelli A, Ricci G, Orzan E.   +9 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Sexual and domestic violence enquiry: A national exploratory survey of asking and telling in sexual health services in the UK. [PDF]

Int J STD AIDS
Meyrick J, Bennett A, McGovern K, Kite C.   +3 more
europepmc   +1 more source