Results 81 to 90 of about 638,033 (344)

Critical exponents of the driven elastic string in a disordered medium

open access: yes, 2005
We analyze the harmonic elastic string driven through a continuous random potential above the depinning threshold. The velocity exponent beta = 0.33(2) is calculated.
H. Gao   +4 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Scaling laws at the critical point

open access: yes, 2006
There are two independent critical exponents that describe the behavior of systems near their critical point. However, at the critical point only the exponent $\eta$, which describes the decay of the correlation function, is usually discussed.
Davatolhagh, S.
core   +1 more source

Exponent-critical groups

open access: yesJournal of Group Theory
Abstract We define and investigate the property of being “exponent-critical” for a finite group. A finite group is said to be exponent-critical if its exponent is not the least common multiple of the exponents of its proper non-abelian subgroups. We explore properties of exponent-critical groups and give a characterization of such groups.
Simon R. Blackburn   +3 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Macroscopic chaos in globally coupled maps

open access: yes, 1998
We study the coherent dynamics of globally coupled maps showing macroscopic chaos. With this term we indicate the hydrodynamical-like irregular behaviour of some global observables, with typical times much longer than the times related to the evolution ...
A. Vulpiani   +26 more
core   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

Percolation Threshold, Fisher Exponent, and Shortest Path Exponent for 4 and 5 Dimensions

open access: yes, 2001
We develop a method of constructing percolation clusters that allows us to build very large clusters using very little computer memory by limiting the maximum number of sites for which we maintain state information to a number of the order of the number ...
A. Bunde   +25 more
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

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