Results 81 to 90 of about 620,813 (298)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Multifractal Analysis Based on p-Exponents and Lacunarity Exponents [PDF]
, 2015 Many examples of signals and images cannot be modeled by locally bounded functions, so that the standard multifractal analysis, based on the Hölder exponent, is not feasible. We present a multifractal analysis based on another quantity, the p-exponent, which can take arbitrarily large negative values. We investigate some mathematical properties of this
Abry, Patrice +4 more
openaire +4 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Delay-Exponent of Bilayer Anytime Code
, 2014 In this paper, we study the design and the delay-exponent of anytime codes over a three terminal relay network. We propose a bilayer anytime code based on anytime spatially coupled low-density parity-check (LDPC) codes and investigate the anytime ...
Lechner, Gottfried +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Journal of Marine Science and Engineering, 2014 Hurricane Irene caused widespread and significant impacts along the U.S. east coast during 27–29 August 2011. During this period, the storm moved across eastern North Carolina and then tracked northward crossing into Long Island and western New England ...
Alfred M. Klausmann
doaj +1 more source
A new algorithm for fast generalized DFTs
, 2018 We give an new arithmetic algorithm to compute the generalized Discrete Fourier Transform (DFT) over finite groups $G$. The new algorithm uses $O(|G|^{\omega/2 + o(1)})$ operations to compute the generalized DFT over finite groups of Lie type, including ...
Hsu, Chloe Ching-Yun, Umans, Chris
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