Results 191 to 200 of about 7,995 (254)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Reliability-based mix design for concrete compressive strength using a physics-prior residual-learning surrogate with calibrated uncertainty. [PDF]

PLoS One
Qu P, Song L, Wang S.
europepmc   +1 more source

Unveiling the Ultralow Thermal Conductivity of Hybrid Perovskites

Advanced Science, EarlyView.
In hybrid perovskites, thermal energy flows through lattice vibrations of the framework (48%–65%) and organic molecules (35%–52%). When the disorder introduced by organic molecules is excluded, the temperature dependence of the vibrational thermal conductivity results from the lattice framework transits from ∼T0 to ∼T−1, and the value doubles at room ...
Qinqin He, Yuli Chen, Zhigang Li, Yanguang Zhou   +3 more
wiley   +1 more source

Anticipating volcanic eruptions using rescaled range analysis of volcano-tectonic seismicity. [PDF]

Sci Rep
Pérez-López R, Guardiola-Albert C, Felpeto A, Sanz-Mangas D, Méndez-Chazarra N, Abella R, Rodríguez-Pascua MA, López-Gutierrez J.   +7 more
europepmc   +1 more source

Flexoelectric Suppression of Interfacial Carrier Loss in BaTiO3 Thin‐Film Bulk Photovoltaic Systems

Advanced Science, EarlyView.
In single‐crystalline BaTiO3 thin films, flexoelectric strain gradients strongly enhance photocurrent by suppressing interfacial carrier loss. Loading experiments reveal a ∼35‐fold photocurrent increase with applied force. Self‐consistent electrostatic modeling shows that strain gradients reshape the interfacial potential landscape, strengthen local ...
Minwoo Jang, Hyunkyu Lim, Sanghoon Yeom, Jaewhan Oh, Yongsoo Yang, Hyungwoo Lee   +5 more
wiley   +1 more source

Restraining Interproton Angular and Distance Dynamics with KEnRef. [PDF]

J Phys Chem B
Alhossary A, Smith CA.
europepmc   +1 more source

Further remarks on the exponent of convergence of Poincaré series

Tohoku Mathematical Journal, 1983
openaire   +3 more sources

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Power Laws in Empirical Eigenvalue Spectra. [PDF]

Entropy (Basel)
Liu B, Chen YY, Li MS, Morgan VT, Abdelaleem E, Sederberg A.   +5 more
europepmc   +1 more source

Substrate Engineering of SWCNT p–n Junctions for Dual‐Mode Power Generation and Heat‐Flux Sensing

Advanced Science, EarlyView.
Through substrate engineering alone, a single‐walled carbon nanotube p–n junction device switches between two functions under uniform infrared irradiation. A low‐absorbance substrate sustains a central hot junction for continuous power generation, whereas high‐absorbance substrates transiently invert the temperature gradient for sensitive heat‐flux ...
Ryota Tamai, Hiroto Nakayama, Shuya Ochiai, Masayuki Takashiri   +3 more
wiley   +1 more source