Results 231 to 240 of about 42,543 (276)

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Delocalisation and Continuity in 2D: Loop  O ( 2 ) , Six-Vertex, and Random-Cluster Models. [PDF]

Commun Math Phys
Glazman A, Lammers P.
europepmc   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Unwanted scenario of medical journals' future: Artificial intelligence and medical writing. [PDF]

Arq Bras Oftalmol
Matsubara S.
europepmc   +1 more source

Principles of bacteriostatic and bactericidal antibiotics at subinhibitory concentrations. [PDF]

mBio
Vaisbourd E, Glass DS, Yang Y, Mayo A, Bren A, Alon U.   +5 more
europepmc   +1 more source

Rethinking body representations in autism across cultures. [PDF]

Front Psychiatry
Mourad J, Grosjean B, Perroud N, Bogaerts K, Desseilles M, Bonnechère B.   +5 more
europepmc   +1 more source

Advancing the understanding of the immune escape in lung cancer immunotherapy: Global trends, collaborations, and future directions. [PDF]

Hum Vaccin Immunother
Li D, Tian J, Zou Y.
europepmc   +1 more source

Dynamic growth trajectories distinguish bacteriostatic and bactericidal antibiotics at subinhibitory concentrations

Vaisbourd E, Glass DS, Yang Y, Mayo A, Bren A, Alon U.   +5 more
europepmc   +1 more source