Results 71 to 80 of about 7,366,599 (370)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Interval Estimation of the Overlapping Coefficient of Two Exponential Distributions

Journal of Statistical Theory and Applications (JSTA), 2019
For the overlapping coefficient between two one-parameter or two-parameter exponential distributions, confidence intervals are developed using generalized pivotal quantities.
Sibil Jose, Seemon Thomas, Thomas Mathew
doaj   +1 more source

An exponentiated geometric distribution

Applied Mathematical Modelling, 2016
Abstract The exponentiated exponential distribution is one of the most seminal distributions of the 20th century. Here, we propose a discrete exponentiated exponential distribution. We derive its mathematical properties and procedures for estimation by common methods. The estimation procedures are assessed by simulation.
Nadarajah, Saraleesan, Bakar, S.A.A.
openaire   +2 more sources

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Distribution of volumes and coordination number in jammed matter: mesoscopic ensemble

, 2010
We investigate the distribution of the volume and coordination number associated to each particle in a jammed packing of monodisperse hard sphere using the mesoscopic ensemble developed in Nature 453, 606 (2008).
Jin, Yuliang, Makse, Hernan A., Song, Chaoming, Wang, Kun, Wang, Ping   +4 more
core   +1 more source

Topological fractal networks introduced by mixed degree distribution [PDF]

, 2006
Several fundamental properties of real complex networks, such as the small-world effect, the scale-free degree distribution, and recently discovered topological fractal structure, have presented the possibility of a unique growth mechanism and allow for ...
Albert, Albert, Amaral, Barabási, Barabási, Csányi, Dorogovtsev, Dorogovtsev, Erdős, Faloutsos, Garlaschelli, Goh, Holme, Jeong, Klemm, Klemm, Liuhua Zou, Mossa, Newman, Newman, Ozik, Ravasz, Ravasz, Song, Song, Strogatz, Tao Li, Vázquez, Vázquez, Watts, Wenjiang Pei, Yiuming Cheung, Yook, Zhenya He   +33 more
core   +2 more sources

Exponentiated power Lindley distribution

Journal of Advanced Research, 2015
A new generalization of the Lindley distribution is recently proposed by Ghitany et al. [1], called as the power Lindley distribution. Another generalization of the Lindley distribution was introduced by Nadarajah et al. [2], named as the generalized Lindley distribution.
Samir K. Ashour, Mahmoud Eltehiwy
openaire   +4 more sources

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Farlie–Gumbel–Morgenstern Bivariate Moment Exponential Distribution and Its Inferences Based on Concomitants of Order Statistics

Stats, 2023
In this research, we design the Farlie–Gumbel–Morgenstern bivariate moment exponential distribution, a bivariate analogue of the moment exponential distribution, using the Farlie–Gumbel–Morgenstern approach.
Sasikumar Padmini Arun, Christophe Chesneau, Radhakumari Maya, Muhammed Rasheed Irshad   +3 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source