Results 31 to 40 of about 42,170 (301)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Nonuniform exponential stability for evolution families on the real line

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2015
The purpose of the present paper is to investigate the problem of nonuniform exponential stability of evolution families on the real line using the input-output technique known in the literature as the Perron method for the study of exponential stability.
Morariu Claudia Isabela, Preda Petre
doaj   +1 more source

A New Family of Exponential Type Estimators in the Presence of Non-Response

Journal of Mathematical and Fundamental Sciences, 2021
We propose families of estimators for the population mean using an exponential function in case of non-response. This situation is examined under two cases, Case I and II. The bias, MSE and minimum MSE are separately obtained for both cases.
Ceren Unal, Cem Kadilar
doaj   +1 more source

Rank verification for exponential families [PDF]

The Annals of Statistics, 2019
Many statistical experiments involve comparing multiple population groups. For example, a public opinion poll may ask which of several political candidates commands the most support; a social scientific survey may report the most common of several responses to a question; or, a clinical trial may compare binary patient outcomes under several treatment ...
Hung, Kenneth, Fithian, William
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A new variance estimation in natural exponential families

Research in Statistics
This article focuses on improving the estimation of population variances for natural exponential family distributions, drawing inspiration from the innovative idea presented by Stein.
Arampamoorthy Laheetharan, Nalini Satkunanathan   +1 more
doaj   +1 more source

On Weak Exponential Expansiveness of Evolution Families in Banach Spaces

The Scientific World Journal, 2013
The aim of this paper is to give several characterizations for the property of weak exponential expansiveness for evolution families in Banach spaces. Variants for weak exponential expansiveness of some well-known results in stability theory (Datko (1973)
Tian Yue, Xiao-qiu Song, Dong-qing Li
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Asymptotic optimality of sequential designs for estimation

International Journal of Mathematics and Mathematical Sciences, 1995
This paper is concerned with the problem of allocating a fixed number of trials between K independent populations from the exponential family, in order to estimate a linear combination of the means with squared error loss.
Kamel Rekab
doaj   +1 more source

Monitoring of Social Network and Change Detection by Applying Statistical Process: ERGM [PDF]

Journal of Optimization in Industrial Engineering, 2020
The statistical modeling of social network data needs much effort  because of the complex dependence structure of the tie variables. In order to formulate such dependences, the statistical exponential families of distributions can provide a flexible ...
Farshid Rajabi, Abbas Saghaei, Soheil Sadinejad   +2 more
doaj   +1 more source