Results 211 to 220 of about 636,793 (279)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

A new family of alpha power-G using cosine function with applications and regression modeling. [PDF]

Sci Rep
Alghamdi AS, ALoufi SF.
europepmc   +1 more source

Geometry quantification for growth assessment of abdominal aortic aneurysms under surveillance. [PDF]

Sci Rep
Restrepo JC, Mitra P, Park H, Baek S, De Oliveira V, Muluk SC, Eskandari MK, Kashyap VS, Finol EA.   +8 more
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

A Review: Construction of Statistical Distributions. [PDF]

Entropy (Basel)
Fang KT, Lin YX, Deng YH.
europepmc   +1 more source

Mapping the Reactivity of the C═C Bond of Cyclic Enol Ether Derivatives of Sugars: Nucleophilicity Parameters of Glycals

Angewandte Chemie International Edition, EarlyView.
Endo or Exo? The first quantitative kinetic mapping of the nucleophilic reactivity of endo‐ and exo‐glycal compounds highlighted that endo‐glycals are typically 102 times less reactive than their corresponding parent cyclic enol ethers while exo‐glycals are 103 more nucleophilic. This experimental and computational structure–reactivity study highlights
Sophie Rodrigues, Saloua Chelli, Jenny Ha, Lucie Pedussaut, Sami Lakhdar, Raphaël Robiette, Stéphane P. Vincent, Guillaume Berionni   +7 more
wiley   +1 more source

The development and implementation of odd-exponential-ailamujia distribution in python: properties and application in reliability engineering. [PDF]

Sci Rep
Alballa T, Ramzan Q, Amin M, Almutairi M, El-Wahed Khalifa HA.   +4 more
europepmc   +1 more source

Towards three-dimensional discrete fracture network modeling using integrated multidimensional outcrop data. [PDF]

Sci Rep
Racolte G, Marques A, Sales V, Zanotta D, Ibanez D, Veronez M, Gonzaga L.   +6 more
europepmc   +1 more source

Intraspecific variation of cochlear morphology in bowhead and beluga whales

The Anatomical Record, EarlyView.
Abstract The bony labyrinth of the petrosal bone, a distinctive feature of mammal skulls, is often identified in micro‐computed tomography imaging to infer species' physiological and ecological traits. When done as part of a comparative study, one individual specimen is normally considered representative of a species, and intraspecific variation is ...
John Peacock, J. G. M. Thewissen
wiley   +1 more source