Results 241 to 250 of about 3,859,005 (290)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +1 more source

Exact solutions and instability analysis of a fifth-order nonlinear evolution equation exhibiting multi-scale wave structures. [PDF]

Sci Rep
Hasan WM, Ahmed HM, Ahmed AM, Rezk HM, Rabie WB.   +4 more
europepmc   +1 more source

Proxy-Based Diagnostics of Quantum Oracle Sketching Robustness for Non-IID Sensor and Telemetry Streams. [PDF]

Sensors (Basel)
Farsi M, Mahmoud M, Helmy A.
europepmc   +1 more source

Impact of Generalized Order Statistics and Its Dual on Entropy Estimation for the Exponentiated Generalized Pham Distribution: Theory and Applications. [PDF]

Entropy (Basel)
Kalantan ZI, Binhimd SMS, Abd Al-Fattah AM, Ahmed AA, Al-Dayian GR, El-Helbawy AA, Abd Elaal MK.   +6 more
europepmc   +1 more source

Identification of genetic determinants that promote biofilm growth under heterotrophic conditions in <i>Cupriavidus necator</i> using transposon enrichment. [PDF]

Biofilm
Weiler JR, Lapp CJ, Gescher J, Edel M.
europepmc   +1 more source

Specific and broad-spectrum antibacterial effectors of type VI secretion system drive competition of <i>Stenotrophomonas rhizophila</i> against bacteria from seed microbiota. [PDF]

Microbiol Spectr
Taillefer B, Dairy Y, Brault A, Briand M, Charpin P, Armengaud J, Sarniguet A.   +6 more
europepmc   +1 more source

A hybrid analytical-machine learning framework for data-driven modeling of soliton solutions in the complex Ginzburg-Landau equation. [PDF]

Sci Prog
Muhammad J, Tedjani AH, Yao F, Younas U.
europepmc   +1 more source

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Simulation in exponential families

ACM Transactions on Modeling and Computer Simulation, 1999
An acceptance-rejection algorithm for the simulation of random variables in statistical exponential families is described. This algorithm does not require any prior knowledge of the family, except sufficient stati stics and the value of the parameter. It allows simulation from many members of the exponential family.
Philippe Barbe, Michel Broniatowski
openaire   +3 more sources