Results 51 to 60 of about 1,498,473 (287)

Simple quasi-exponential slope generator [PDF]

open access: yes, 1969
Circuitry for digitally generating an exponentially decaying wave function permits discrete values to be sampled from the exponential waveform for comparison with a binary number of specified accuracy.
Anderson, T. O., Hurd, W. J.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

On a New Integral Inequality: Generalizations and Applications

open access: yesAxioms, 2022
In this paper, we present some generalizations and improvements of a new integral inequality from the 29th IMC in 2022. Some applications of our new results are also provided.
Huaping Huang, Wei-Shih Du
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A Novel Measure of Uncertainty in the Dempster-Shafer Theory

open access: yesIEEE Access, 2020
In the Dempster-Shafer theory, how to quantitatively evaluate the quality of information is an essential issue and also an open issue. Many of measures of uncertainty have been proposed in previous work, whereas some measures among them had been proved ...
Ke Wen   +3 more
doaj   +1 more source

Exploring the Potential of Zirconium-89 in Diagnostic Radiopharmaceutical Applications: An Analytical Investigation

open access: yesBiomedicines, 2023
This study highlights the use of 89Zr-oxalate in diagnostic applications with the help of WinAct and IDAC2.1 software. It presents the biodistribution of the drug in various organs and tissues, including bone, blood, muscle, liver, lung, spleen, kidneys,
Ahmed M. A. Mostafa   +5 more
doaj   +1 more source

A Note on Schanuel's Conjectures for Exponential Logarithmic Power Series Fields

open access: yes, 2012
In [1], J. Ax proved a transcendency theorem for certain differential fields of characteristic zero: the differential counterpart of the still open Schanuel's conjecture about the exponential function over the field of complex numbers [11, page 30].
Kuhlmann, Salma   +2 more
core   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Evaluación del desarrollo de competencias a partir de la modelación matemática

open access: yesIngenierías USBMed, 2019
In the present study, an educational intervention was carriedout in eleven graders belonging to the St. Vincent de Paul educationalinstitution in the city of Medellín, in order to build the concept ofexponential function in a meaningful way under the ...
Carlos Márquez   +2 more
doaj   +1 more source

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