Results 61 to 70 of about 7,472,397 (345)
The Human Ecology of Overshoot: Why a Major ‘Population Correction’ Is Inevitable
World, 2023 Homo sapiens has evolved to reproduce exponentially, expand geographically, and consume all available resources. For most of humanity’s evolutionary history, such expansionist tendencies have been countered by negative feedback.
William E. Rees
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Geodesic growth in virtually abelian groups
, 2020 We show that the geodesic growth function of any finitely generated virtually abelian group is either polynomial or exponential; and that the geodesic growth series is holonomic, and rational in the polynomial growth case.
Bishop, Alex
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Size-Specific Growth of Filter-Feeding Marine Invertebrates
Journal of Marine Science and Engineering, 2022 Filter-feeding invertebrates are found in almost all of the animal classes that are represented in the sea, where they are the necessary links between suspended food particles (phytoplankton and free-living bacteria) and the higher trophic levels in the ...
Poul S. Larsen, Hans Ulrik Riisgård
doaj +1 more source
Correcting misperceptions of exponential coronavirus growth increases support for social distancing
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Given the current lack of an effective vaccine to prevent coronavirus disease 2019 (COVID-19), one of the most effective ways to prevent the illness is social distancing.
J. Lammers, J. Crusius, A. Gast
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Gels, 2018 Despite intense recent interest in weakly bound nonlinear (“exponential”) multilayers, the underlying structure-property relationships of these films are still poorly understood.
Victor Selin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source