Results 71 to 80 of about 7,472,397 (345)
Generalized Lyapunov exponent as a unified characterization of dynamical instabilities
, 2014 The Lyapunov exponent characterizes an exponential growth rate of the difference of nearby orbits. A positive Lyapunov exponent is a manifestation of chaos.
Aizawa, Yoji +3 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Choquard equations with critical exponential nonlinearities in the zero mass case
AIMS MathematicsWe investigate Choquard equations in $ \mathbb R^N $ driven by a weighted $ N $-Laplace operator with polynomial kernel and zero mass. Since the setting is limiting for the Sobolev embedding, we work with nonlinearities which may grow up to the critical
Giulio Romani
doaj +1 more source
Probing Mammalian Cell Size Homeostasis by Channel-Assisted Cell Reshaping
Cell Reports, 2017 Cell size homeostasis can be achieved by size checkpoints that couple cell size to cell-cycle progression or by alternative mechanisms such as constant extension.
Giulia Varsano, Yuedi Wang, Min Wu
doaj +1 more source
Mycobacterial SigA and SigB Cotranscribe Essential Housekeeping Genes during Exponential Growth
mBio, 2019 All mycobacteria encode a group II sigma factor, σB, closely related to the group I principal housekeeping sigma factor, σA. Group II sigma factors are widely believed to play specialized roles in the general stress response and stationary-phase ...
Kelley R. Hurst-Hess +5 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Journal of Visualized Experiments, 2018 Saccharomyces cerevisiae cells in the exponential phase sustain their growth by producing ATP through fermentation and/or mitochondrial respiration. The fermentable carbon concentration mainly governs how the yeast cells generate ATP; thus, the variation
Ivanna K Olivares-Marin +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Antimicrobial activity of cationic antimicrobial peptides against stationary phase bacteria
Frontiers in Microbiology, 2022 Antimicrobial peptides (AMPs) are ancient antimicrobial weapons used by multicellular organisms as components of their innate immune defenses. Because of the antibiotic crisis, AMPs have also become candidates for developing new drugs. Here, we show that
Alexandro Rodríguez-Rojas +3 more
doaj +1 more source