Results 51 to 60 of about 502,181 (273)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Goldbach partitions and norms of cusp forms

Journal of Numerical Analysis and Approximation Theory, 2019
An integral formula for the Goldbach partitions requires uniform convergence of a complex exponential sum. The dependence of the coefficients of the series is found to be bounded by that of cusp forms.
Simon Brian Davis
doaj   +7 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Optimal homotopy asymptotic method for solving Volterra integral equation of first kind

Alexandria Engineering Journal, 2014
In this paper, authors demonstrate the efficiency of optimal homotopy asymptotic method (OHAM). This is done by solving nonlinear Volterra integral equation of first kind.
N. Khan, M.S. Hashmi, S. Iqbal, T. Mahmood   +3 more
doaj   +1 more source

Coboundaries under Integrable Exponentiation

Tokyo Journal of Mathematics, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Validity and error analysis of calculating matrix exponential function and vector product

Nonlinear Engineering
In this study, an efficient calculation method of matrix exponential function and vector product is proposed to reduce the calculation error. This method is based on the flexible exponential integral scheme; using B-series theory and two-color tree ...
Tu Lihui, Hong Huanjie
doaj   +1 more source

Computing Exponential for Iterative Splitting Methods: Algorithms and Applications

Journal of Applied Mathematics, 2011
Iterative splitting methods have a huge amount to compute matrix exponential. Here, the acceleration and recovering of higher-order schemes can be achieved.
Jürgen Geiser
doaj   +1 more source

Design of Integral Controllers for Nonlinear Systems Governed by Scalar Hyperbolic Partial Differential Equations

, 2017
The paper deals with the control and regulation by integral controllers forthe nonlinear systems governed by scalar quasi-linear hyperbolic partial differentialequations.
Andrieu, Vincent, Trinh, Ngoc-Tu, Xu, Cheng-Zhong   +2 more
core   +3 more sources