Results 41 to 50 of about 15,801 (247)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Geometric, Variational Discretization of Continuum Theories

, 2010
This study derives geometric, variational discretizations of continuum theories arising in fluid dynamics, magnetohydrodynamics (MHD), and the dynamics of complex fluids.
Desbrun, Mathieu, Gawlik, Evan S., Marsden, Jerrold E., Mullen, Patrick, Pavlov, Dmitry   +4 more
core   +1 more source

Coboundaries under Integrable Exponentiation

Tokyo Journal of Mathematics, 1992
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Shared-Pole Carathéodory–Fejér Approximations for Linear Combinations of φ-Functions

Mathematics
We develop a shared denominator Carathéodory–Fejér (CF) method for efficiently evaluating linear combinations of φ-functions for matrices whose spectrum lies in the negative real axis, as required in exponential integrators for large stiff ODE systems ...
Awad H. Al-Mohy
doaj   +1 more source

Phase-fitted Discrete Lagrangian Integrators

, 2009
Phase fitting has been extensively used during the last years to improve the behaviour of numerical integrators on oscillatory problems. In this work, the benefits of the phase fitting technique are embedded in discrete Lagrangian integrators.
Brusa, Cadzow, D.S. Vlachos, Gautschi, Ixaru, Ixaru, Ixaru, Jordan, Lee, Leok, Logan, Lyche, Maeda, Maeda, Marsden, Marsden, Monovasilis, Monovasilis, O.T. Kosmas, Quinlan, Simos, Van Daele, Vanden Berghe, Vanden Berghe, Vanden Berghe   +24 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Distributed strategies for pursuit-evasion of high-order integrators

Autonomous Intelligent Systems
This paper presents decentralized solutions for pursuit-evasion problems involving high-order integrators with intracoalition cooperation and intercoalition confrontation.
Panpan Zhou, Yueyue Xu, Bo Wahlberg, Xiaoming Hu   +3 more
doaj   +1 more source

Postprocessed integrators for the high order integration of ergodic SDEs

, 2014
The concept of effective order is a popular methodology in the deterministic literature for the construction of efficient and accurate integrators for differential equations over long times.
Vilmart, Gilles
core   +4 more sources