Results 51 to 60 of about 15,801 (247)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Modelling heat and mass transfer in electro-osmosis flow of williamson nano-fluids using a hybrid scheme

Partial Differential Equations in Applied Mathematics
This paper presents a computational scheme for solving time-dependent partial differential equations (PDEs) arising from the study of electro-osmosis flow of Williamson nano-fluids, which is significant for optimizing microfluidic and biomedical ...
Muhammad Shoaib Arif, Kamaleldin Abodayeh, Yasir Nawaz   +2 more
doaj   +1 more source

Multimodal Mechanical Testing of Additively Manufactured Ti6Al4V Lattice Structures: Compression, Bending, and Fatigue

Advanced Engineering Materials, EarlyView.
In this experimental study, the mechanical properties of additively manufactured Ti‐6Al‐4V lattice structures of different geometries are characterized using compression, four point bending and fatigue testing. While TPMS designs show superior fatigue resistance, SplitP and Honeycomb lattice structures combine high stiffness and strength. The resulting
Klaus Burkart, Jonas Schmidt, Anastasiya Toenjes, Johanna Eisenträger   +3 more
wiley   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

Towards Robust Variational Quantum Simulation of Lindblad Dynamics via Stochastic Magnus Expansion

PRX Quantum
Dedicated to the centenary of quantum mechanics. In this paper, we introduce a novel and general framework for the variational quantum simulation of Lindblad equations.
Jia-Cheng Huang, Hao-En Li, Yi-Cheng Wang, Guang-Ze Zhang, Jun Li, Han-Shi Hu   +5 more
doaj   +1 more source

A Flexible High-Accuracy Memristor Model Using Varactors

IEEE Access
This paper introduces a novel compact memristor model that encompasses various phenomena such as linear and nonlinear dopant drifts, exponential drifts of dopants in high electric fields, asymmetry in the on and off switching, and threshold effects. This
Mahdi Tarkhan, Hui Wu, Fateh Ullah, Mohamad Sawan   +3 more
doaj   +1 more source

3D‐Printed Giant Magnetoresistive (GMR) Sensors Based on Self Compliant Springs

Advanced Engineering Materials, EarlyView.
This work explores 3D‐printed GMR sensors utilizing self‐compliant spring structures and conductive PLA composites. By optimizing arm width, we achieved high piezoresistive (0.34%/mm) and magnetoresistive (0.77%/mT) sensitivities. Demonstrated through Bluetooth‐integrated pressure and magnetic position sensing, these full printed low‐cost, customizable
Josu Fernández Maestu, Nelson Pereira, Javier Vicente, Carmen Rial Tubio, Senentxu Lanceros‐Méndez   +4 more
wiley   +1 more source

Semi-Implicit Numerical Integration of Boundary Value Problems

Mathematics
The numerical solution to boundary differential problems is a crucial task in modern applied mathematics. Usually, implicit integration methods are applied to solve this class of problems due to their high numerical stability and convergence.
Maksim Galchenko, Petr Fedoseev, Valery Andreev, Endre Kovács, Denis Butusov   +4 more
doaj   +1 more source