Results 51 to 60 of about 1,512,653 (346)

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Nikolskii Type Inequalities for Entire Functions of Exponential Type in Lorentz Zygmund Spaces [PDF]

open access: yesarXiv, 2021
Nikolskii type inequalities for entire functions of exponential type on Rn for the Lorentz Zygmund spaces are obtained. Some new limiting cases are examined. Application to Besov type spaces of logarithmic smoothness is given.
arxiv  

Generalized Semi Exponential Type Estimator under Systematic Sampling

open access: yesJournal of Statistical Theory and Applications (JSTA), 2018
In sample surveys, collection of auxiliary information together with the main variable of interest is very important to increase the efficiency of the estimators of population parameters of interest.
Muhammad Nouman Qureshi   +2 more
doaj   +1 more source

Some Matrix-Variate Models Applicable in Different Areas

open access: yesAxioms, 2023
Matrix-variate Gaussian-type or Wishart-type distributions in the real domain are widely used in the literature. When the exponential trace has an arbitrary power and when the factors involving a determinant and a trace enter into the model or a matrix ...
Arak M. Mathai
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Multivalence of bivariate functions of bounded index

open access: yesLe Matematiche, 2015
This paper examines the relationship between the concept of bounded index and the radius of equivalence, respectively p-valence, of entire bivariate functions and their partial derivatives at arbitrary points in C^2.
Fatih Nuray, Richard F. Patterson
doaj  

A Matrix-Analytic Solution for Randomized Load Balancing Models with Phase-Type Service Times [PDF]

open access: yes, 2010
In this paper, we provide a matrix-analytic solution for randomized load balancing models (also known as \emph{supermarket models}) with phase-type (PH) service times.
Li, Quan-Lin   +2 more
core  

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

The weighted Lindley exponential distribution and its related properties

open access: yesAIMS Mathematics, 2023
Both the exponential and Lindley distributions can be used to model the lifetime of a system or process, as well as the distribution of waiting times.
Doaa Basalamah, Bader Alruwaili
doaj   +1 more source

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