Results 241 to 250 of about 719,145 (360)

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang   +6 more
wiley   +1 more source

The nuclear envelope and nuclear pore complexes in neurodegenerative diseases. [PDF]

open access: yesFront Cell Dev Biol
Wu T   +5 more
europepmc   +1 more source

Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture

open access: yesAdvanced Science, EarlyView.
This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis   +7 more
wiley   +1 more source

Spillovers, Foreign Investment, and Export Behavior

open access: yes, 1994
Brian Aitken   +2 more
semanticscholar   +1 more source

Inverse Design of Highly Deformable Mechanical Metamaterial Based on Partitional Semi‐Random Optimization

open access: yesAdvanced Science, EarlyView.
This research presents a novel optimization method for the inverse design of flexible mechanical metamaterials, enhancing traditional strategies by evaluating deformation in subregions. Combining simulated annealing with a genetic algorithm, it improves design efficiency and enables customizable deformation paths.
Xueqing Cao   +4 more
wiley   +1 more source

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