Results 261 to 270 of about 719,145 (360)

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

open access: yesAdvanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song   +37 more
wiley   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

open access: yesAdvanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich   +8 more
wiley   +1 more source

Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing

open access: yesAdvanced Science, EarlyView.
A novel microphysiological system that can mimic sterile or non‐sterile injury demonstrates that macrophage‐derived extracellular vesicles modulate neutrophil migratory responses to these different wound states. The model showed that resolution of inflammation through neutrophil reverse migration is driven by IL‐8 derived from extracellular vesicles ...
Kehinde Adebayo Babatunde   +5 more
wiley   +1 more source

Commodity risk assessment of <i>Berberis thunbergii</i> plants from the UK. [PDF]

open access: yesEFSA J
EFSA Panel on Plant Health (PLH)   +36 more
europepmc   +1 more source

Catalytic Hairpin Assembly‐Propelled Weak‐Inputs‐Strong‐Outputs (CP‐WISO) DNA Logic Nanodevices with Orthogonal Design and Contrary Logic Responses

open access: yesAdvanced Science, EarlyView.
Catalytic hairpin assembly‐propelled weak‐inputs‐strong‐outputs (CP‐WISO) DNA logic nanodevices with orthogonal design and contrary logic responses are innovatively fabricated. Moreover, the even and odd parity generators/checkers for ensuring normal molecular data transmission, and the logic‐programmed miRNA biosensors with ratiometric fluorescent ...
Xujuan Lv   +8 more
wiley   +1 more source

Mechanisms of heme transport in the mitochondria. [PDF]

open access: yesBiochem Soc Trans
Ali SF   +3 more
europepmc   +1 more source

Upcycling of Waste Fluororubber to Photocurable High‐Performance Vinyl‐Terminated Liquid Fluororubber by Multifield Coupling One‐Pot Stepwise Reactions

open access: yesAdvanced Science, EarlyView.
Herein, waste fluororubbers undergo controlled oxidative degradation induced by alkali and hydrogen peroxide to yield carboxyl terminated liquid fluororubbers. Subsequently, condensation reaction system efficiently converts carboxyl groups into photoreactive vinyl groups.
Donghan Li   +12 more
wiley   +1 more source

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