Results 291 to 300 of about 719,145 (360)

Differential xylem phytohormone export from dry and wet roots during partial rootzone drying is independent of shoot-to-root transport in soybean. [PDF]

Physiol Plant
Puértolas J, Castro-Valdecantos P, Albacete A, Dodd IC.   +3 more
europepmc   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Single‐Cell RNA Sequencing Identifies MMP11+ Cancer‐Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression

Advanced Science, EarlyView.
Single‐cell RNA sequencing identifies MMP11⁺ CAFs as pro‐angiogenic cells accumulating during bladder cancer progression. These cells promote angiogenesis by regulating ESM1⁺ tip endothelial cells and recruiting SPP1⁺ macrophages. Tumor‐derived BMP2 promotes their activation.
Wuwu Xu, Ting Liang, Hu Fang, Lu Fu, Dashi Deng, Xiyang Tan, Lisha Liu, Dongdong Tang, Haoxiang Zheng, Qiuxia Ding, Xiuqi Hou, Daquan Feng, Tao Tao, Song Wu   +13 more
wiley   +1 more source

Assessing competitiveness and complementarity in agricultural trade between China and Cambodia pre-pandemic and post-pandemic. [PDF]

PLoS One
Tao Z, Ramasamy SS, Naktnasukanjn N, Ying F.   +3 more
europepmc   +1 more source

tRF‐5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Acute respiratory distress syndrome (ARDS) is a severe lung condition with limited treatments, often triggered by overactive endothelial cells (ECs). It is identified that macrophage‐derived secretory autophagosomes (MSAPs) exacerbate lung damage by activating EC function.
Xing‐xing Zhu, Han Li, Shuang‐feng Zi, Ying Tang, Na Liu, Ke‐xin Li, Shi‐ke Geng, Hui‐qing Lu, Zhi‐kang Xie, Xin‐yi Xu, Yi‐ting Wei, Li‐xin Wang, Tao Liu, Jie Chao, Yi Yang, Hai‐bo Qiu, Wei Huang, Ling Liu   +17 more
wiley   +1 more source

Coupling mechanisms coordinating mRNA translation with stages of the mRNA lifecycle. [PDF]

RNA Biol
Famà V, Coscujuela Tarrero L, Albanese R, Calviello L, Biffo S, Pelizzola M, Furlan M.   +6 more
europepmc   +1 more source

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer

Advanced Science, EarlyView.
We show that intratumoral release of an immunotherapy—CpG —can be tuned with molecular precision by complexing it to an elastin‐like polypeptide (ELP). Injecting ELP‐CpG and an excipient ELP into tumors drives thermally‐triggered phase separation into a micro‐scale “sponge” depot that releases CpG at rates depending on the ELP composition, which ...
Joshua J. Milligan, Rachel L. Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C. Su, Anastasia K. Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes, Anna Finkelstein, Rohinee Mattikalli, Yun‐Xing Wang, Lixin Fan, Xinghai Li, Smita K. Nair, Ashutosh Chilkoti   +16 more
wiley   +1 more source

The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development. [PDF]

PLoS Genet
Strohdiek A, Köhler AM, Harting R, Stupperich H, Gerke J, Bastakis E, Neumann P, Ahmed YL, Ficner R, Braus GH.   +9 more
europepmc   +1 more source

Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells

Zaganelli S, Meehl JB, Abrisch RG, Voeltz GK.   +3 more
europepmc   +1 more source

ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA. [PDF]

Nucleic Acids Res
Soderholm A, Vunjak M, de Almeida M, Popitsch N, Podvalnaya N, Araguas-Rodriguez P, Scinicariello S, Nischwitz E, Butter F, Ketting RF, Ameres SL, Müller-McNicoll M, Zuber J, Versteeg GA.   +13 more
europepmc   +1 more source