Results 301 to 310 of about 1,916,844 (345)

Export of evidence-based wellness services: An opportunity to actualize India's demographic dividend. [PDF]

J Ayurveda Integr Med
Sarwal R, Bhargav H, Narayanan Gopalakrishnan B.   +2 more
europepmc   +1 more source

Genetic Manipulation of Mammalian Cells in Microphysiological Hydrogels

Advanced Science, EarlyView.
Supply channels for cells embedded in gels can be used for in situ genetic manipulation. Abstract Engineering functional 3D tissue constructs is essential for developing advanced organ‐like systems, with applications ranging from fundamental biological research to drug testing. The generation of complex multicellular structures requires the integration
Anna C. Jäkel, Dong‐Jiunn Jeffery Truong, Friedrich C. Simmel   +2 more
wiley   +1 more source

Integrated export instream coefficient model for accurate nonpoint source pollution estimation and management in the Yellow River Basin. [PDF]

Sci Rep
Wang X, Wu L, Luo Y, Liu Y, Wang R.
europepmc   +1 more source

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

Spatial and temporal patterns of foot and mouth disease outbreaks (2011-2022) in cattle export-sourcing areas of southeastern Ethiopia. [PDF]

BMC Vet Res
Gizaw D, Beyene G, Ashenafi H, Legesse M, Kassa T.   +4 more
europepmc   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

Glutathione Metabolism of the Brain-The Role of Astrocytes. [PDF]

J Neurochem
Dringen R, Arend C.
europepmc   +1 more source

Quorum Sensing Inhibits Type III‐A CRISPR‐Cas System Activity Through Repressing Positive Regulators SarA and ArcR in Staphylococcus Aureus

Advanced Science, EarlyView.
This study proposes a novel model illustrating how quorum sensing (QS) regulates the type III‐A CRISPR‐Cas system in Staphylococcus aureus. The QS regulator AgrA suppresses CRISPR‐Cas activity by downregulating the transcriptional regulators SarA and ArcR.
Yang Li, Yuanyue Tang, Xiaofei Li, Nina Molin Høyland‐Kroghsbo, Hanne Ingmer, Xinan Jiao, Qiuchun Li   +6 more
wiley   +1 more source

The hidden power of antisense long non-coding RNAs: a dive into a novel regulatory layer mediated by double-stranded RNA formation. [PDF]

RNA Biol
Lamping JP, Krebber H.
europepmc   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source