Results 251 to 260 of about 533,596 (298)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Review of large YOLOv8 and RT-DETR energy efficiency on edge devices for real-time detection. [PDF]

Sci Rep
Suchý I, Turčaník M.
europepmc   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Analysis of the spatio-temporal evolution of iron ore trade from a geopolitical perspective: A complex network model. [PDF]

PLoS One
Huang S, Cai C, Fu B.
europepmc   +1 more source

Topology‐Enriched Toughness Enhancement in Quasi‐Periodic Metastructures Featuring Tailorable Strong‐Weak Network

Advanced Science, EarlyView.
A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao, Genda Wang, Jiabao Bai, Kai Liu   +3 more
wiley   +1 more source

How metaverse-enabled digital transformation drives sustainable supply chain innovation: evidence from Pakistan's textile industry. [PDF]

Sci Rep
Abdullah M, Ullah A, Jamal MF, Aldakheel EA, Khafaga DS, Ashraf S, Rasool Z.   +6 more
europepmc   +1 more source

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source

Potential economy-wide impacts of an African swine fever outbreak in the United States. [PDF]

Front Vet Sci
de Menezes TC, Countryman AM, Pendell DL, Rushton J, Tickel J, Simmons H.   +5 more
europepmc   +1 more source

Machine learning-assisted abstract screening on learning analytics: a step-by-step tutorial. [PDF]

Syst Rev
Xu Z, Ma S, Zhuang X, Adeyemi AE, Kogut A.   +4 more
europepmc   +1 more source

Alzheimer's disease as a systems-level timing disorder: Circadian disruption of glial immunometabolism, brain clearance, and therapeutic responsiveness. [PDF]

Neurobiol Sleep Circadian Rhythms
Bach DH, Nguyen TL.
europepmc   +1 more source