Results 231 to 240 of about 6,797 (283)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Edible Insect Production in Thailand: Sustainable Supply Chain Management. [PDF]

Insects
Krongdang S, Venkatachalam K, Chitov T, Wangtueai S, Wongsa J, Parametthanuwat T, Charoenphun N.   +6 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

A bibliometric analysis of global health curriculum teaching models: Current status, hotspots, and trends in higher education between 2014 and 2024. [PDF]

Glob Health Res Policy
Qian B, Li Y, Wu B, Lu Y, Tang K.
europepmc   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Growth, development, and health status of primary school students in Binzhou city: an analysis based on health examination data for 6-12-Year-olds. [PDF]

Front Public Health
Li S, Wang X.
europepmc   +1 more source

The Reasons to Get Vaccinated: A Cross-Sectional Study on HPV Vaccination Adherence in a Northern Italian University. [PDF]

Vaccines (Basel)
Perrone PM, Zanzi R, Biganzoli E, Pregliasco F, Castaldi S.   +4 more
europepmc   +1 more source

Development of a Collaborative Education Program for Home Care Nursing Educators' on-the-Job Training in End-of-Life Home Care: Protocol for a Randomized Controlled Trial. [PDF]

JMIR Res Protoc
Yamada R, Numata H, Sumikawa Y, Kashiwabara K, Noguchi-Watanabe M, Kurita K, Yamamoto-Mitani N.   +6 more
europepmc   +1 more source

Assessing Social Drivers of Health Among Pediatric Solid Organ Transplant Patients Using Psychosocial Screening: Rates of Risk and What DO we DO? [PDF]

Pediatr Transplant
Rea KE, Dusing C, Fredericks KG, Swaminathan S, Cousino MK, Fredericks EM.   +5 more
europepmc   +1 more source