Results 141 to 150 of about 7,001,402 (299)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Population headliners. No.299, March-April 2004 [PDF]
, 2004 The newsletter is produced with support from the United Nations Population Fund (UNFPA), Project No. RAS5P203 ESCAP's project on population approved ... 2 2004 United Nations Population Award ... 3 ESCAP releases 2004 Population Data Sheet ...
United Nations Population Fund (UNFPA) +1 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
IMMUNOHAEMATOLOGICAL AND CYTOGENETICAL STUDIES ON HUMAN POPULATION EXPOSED TO SULFUR MUSTARD [PDF]
Journal of Sciences, Islamic Republic of Iran, 2002 The patients evaluated in this study were classified into three groups of severe, moderate, and mild according to the severity of exposure to sulfur mustard.
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Biomarkers of metabolic disorders and neurobehavioral diseases in a PCB- exposed population: What we learned and the implications for future research. [PDF]
Environ Res, 2020 Simhadri JJ +8 more
europepmc +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Chromosomal Study on Lead Exposed Population
INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2013 Exposure to extremely toxic substance like lead might lead to a broad range of undesirable health consequences. As a result of lead poisoning both adults and children experience adverse physical conditions. The objective of the present study is to estimate the level of lead in the blood of the exposed population and analyze the haematological ...
openaire +1 more source