Results 61 to 70 of about 106,708 (270)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Ottoman Representation in Nineteenth Century Universal Expositions

Megaron, 2015
The post-1815 years of the Industrial Revolution witnessed the growth of international free trade, prompted by the opening up of new markets, accumulation of capital, and the bountiful supply of cheap raw materials made available by colonization.
Yeşim Duygu Ergüney, Nuran Kara Pilehvarian   +1 more
doaj   +1 more source

Retracing Augustine’s Ethics: Lying, Necessity, and the Image of God [PDF]

, 2016
Augustine’s exposition of the image of God in Book 15 of On The Trinity (De Trinitate) sheds light on multiple issues that arise in scholarly interpretations of Augustine’s account of lying.
Puffer, Matthew
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Il potere dell’architettura. L’ideologia di regime all’Esposizione Internazionale di Parigi 1937

Diacronie. Studi di Storia Contemporanea, 2014
The political crackdown during the 20th Century finds in the International Events a special place for the hosting Countries to spread their ideologies to the visitors and to all the other Countries attending the event.
Guido Cimadomo è architetto laureato al Politecnico di Milano e dottore di ricerca all’Università di Siviglia. È Profesor Asociado alla Facoltà di Architettura dell’Università di Malaga, dove insegna Storia dell’Architettura; coordinatore accademico per la mobilità internazionale, expert member del comitato scientifico CIPA per la documentazione del patrimonio culturale, sotto l’egida di ICOMOS, e membro attivo del Forum Unesco Università e Patrimonio., Renzo Lecardane è architetto e dottore di ricerca all’Università di Palermo e all’Ecole Nationale des Ponts et Chaussées (ENPC-Paris). È Professore Associato di «Composizione architettonica e urbana» presso la Scuola Politecnica dell’Università di Palermo. Membro del Dipartimento di Architettura (d’ARCH-UNIPA) e del Laboratoire Infrastructure Architecture et Territoire (ENSA Paris-Malaquais), dal 2009 è componente del Collegio del Dottorato di Ricerca in «Recupero e fruizione dei contesti antichi».   +1 more
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

1917 : trois expositions en débat

Cahiers d’histoire, 2019
Le 19 décembre 2017, à l’initiative des Cahiers d’histoire représentés par Anne Jollet (rédactrice en chef) et Pascal Guillot (membre du comité de rédaction de la revue), les commissaires de trois expositions portant sur l’année 1917 en Russie se sont ...
Alain Blum, Valérie Tesnière, Éric Lafon, Frédérick Genevée, Anne Jollet   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source