Results 281 to 290 of about 8,026,862 (350)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Copper-Induced Thyroid Disruption and Oxidative Stress in <i>Schizopygopsis younghusbandi</i> Larvae. [PDF]

Antioxidants (Basel)
Zhong L, Zhang C, Liu F, Gao H, Di D, Yao F, Ma B, Liu M, Duan X.   +8 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Development of a novel humanized gut-brain axis model as a tool toward personalized nutrition. [PDF]

Commun Biol
Chatzopoulou MS, Vumma R, Prado S, Scharf MW, Castro-Alves V, Hutchinson AN, Rangel I, Marques TM, Wall R, Brummer RJ, Rode J.   +10 more
europepmc   +1 more source

Objective Measurement of Light Exposure and Eye Growth in Children over One Year

, 2016
Auzita Sajjadi, Lisa A. Ostrin
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

<i>In Vitro</i> Model Exploring the Mechanisms of Dextrose Prolotherapy: Fibroblasts Exposed to Clinical Concentrations of Dextrose Exhibit Significant Rebound Effects 48 Hours After Exposure. [PDF]

Cartilage
Harting BR, Fox SK, Foster AD, Motyka TM, Hinkelman AN.   +4 more
europepmc   +1 more source

Virtuelle und reale Objekte als natürliche Bewegungsgrenzen in der Virtual Reality Exposure Therapy

, 2019
Matthias Lüönd
openalex   +1 more source

Mediating role of metabolic dysfunction-associated fatty liver disease in the association between individual-level noise exposure and liver enzymes in Chinese automotive manufacturing workers. [PDF]

Int Arch Occup Environ Health
Ou S, Yu J, Chen Z, Ruan Y, Rong X, Ou Z, Zhang Y, Huang H, Cui J, Wang Z.   +9 more
europepmc   +1 more source