Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Development of longitudinal datasets (2000-2020) with high spatiotemporal resolution for air pollution exposure assessment in Canada. [PDF]
Alhusban A +11 more
europepmc +1 more source
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
Dietary exposure assessment to nickel through the consumption of poultry, beef, and pork meat for different age groups in the Italian population. [PDF]
Manfredi A +8 more
europepmc +1 more source
An assessment of occupational exposure to inhalable aerosols and airborne proteins in food manufacturing plants [PDF]
Christine Darbakk +2 more
openalex +1 more source
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Machine learning-enhanced high-resolution exposure assessment of ultrafine particles. [PDF]
Jianyao Y +5 more
europepmc +1 more source
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Escape Room Versus Traditional Simulation: A Comparative Study of the A-E (Airway, Breathing, Circulation, Disability, Exposure) Assessment in Undergraduate Medical Training. [PDF]
Hussaini N +4 more
europepmc +1 more source

