Results 91 to 100 of about 1,270,191 (298)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Combined nutritional stress and a new systemic pesticide (flupyradifurone, Sivanto®) reduce bee survival, food consumption, flight success, and thermoregulation. [PDF]
, 2019 Flupyradifurone (FPF, Sivanto®) is a new butenolide insecticide that, like the neonicotinoids, is a systemic nicotinic acetylcholine receptor (nAChR) agonist.
Nieh, James C, Tong, Linda, Tosi, Simone
core +4 more sources
The zebrafish gut microbiome influences benzo[a]pyrene developmental neurobehavioral toxicity
Scientific ReportsEarly-life exposure to environmental toxicants like Benzo[a]pyrene (BaP) is associated with several health consequences in vertebrates (i.e., impaired or altered neurophysiological and behavioral development).
Keaton Stagaman +7 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Learning from Madoff: Lessons for Foundation Boards [PDF]
, 2009 More than 80 percent of foundations that lost between 30 to 100 percent of their assets to Bernard Madoff's Ponzi scheme had fewer than five trustees serving on their boards.
Julia Craig, Niki Jagpal
core
An Empirical Evaluation Of Social Influence Metrics
, 2016 Predicting when an individual will adopt a new behavior is an important problem in application domains such as marketing and public health. This paper examines the perfor- mance of a wide variety of social network based measurements proposed in the ...
Aleali, Ashkan +3 more
core +1 more source
Exposure to STEM: Diversity in Maritime Transportation
, 2019 Although the 1954 U.S. Supreme Court decision in the case of Brown vs. Board of Education declared state laws establishing segregated public schools unconstitutional, in 1957 Arkansas Governor Orval Faubus tried to prevent nine African American students from attending school at Little Rock Central High School (LRCHS). Faubus’ attempt to block access to
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2014 Ground-based ultra-high contrast imaging, as required for direct imaging of exoplanets and other solar systems, is limited by difficulty of separating the planetary emission from the effects of optical aberrations that are not compensated by the adaptive
Frazin, Richard A.
core +1 more source