Results 101 to 110 of about 4,930,320 (325)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Theorizing the Relationship Between Identity and Diversity Engagement: Openness Through Identity Mismatch [PDF]

, 2018
Psychological research suggests that engagement with diversity-relevant materials can have a positive impact on interracial relations. However, prior research also suggests that there may be individual differences in how effective exposure to critical ...
Haugen, A.D., Mukherjee, S., Perez, M.J., Rieck, S.M., Salter, P.S.   +4 more
core   +1 more source

Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus [PDF]

, 2014
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults.
A. Rambaut, Adalja, Antonovics, Davenport, Dowdle, Fan, FROST, G.-Z. Han, Kawaoka, KENDAL, M. Worobey, Masurel, Masurel, Masurel, Masurel, Molinari, Morens, Mulder, Nelson, REKART, SCHOENBAUM, Schulman, Shanks, Shanks, Taubenberger, Thompson, Thompson, Waffarn, Webster, Wolfe   +29 more
core   +2 more sources

Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis

Scientific Reports, 2019
In persons with cystic fibrosis (CF), decreased airway microbial diversity is associated with lower lung function. Conflicting data exist on the impact of short-term antibiotics for treatment of acute pulmonary exacerbations. However, whether differences
A. Hahn, H. Fanous, C. Jensen, H. Chaney, I. Sami, Geovanny F. Perez, A. Koumbourlis, S. Louie, J. Bost, J. N. van den Anker, R. Freishtat, E. Zemanick, K. Crandall   +12 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The zebrafish gut microbiome influences benzo[a]pyrene developmental neurobehavioral toxicity

Scientific Reports
Early-life exposure to environmental toxicants like Benzo[a]pyrene (BaP) is associated with several health consequences in vertebrates (i.e., impaired or altered neurophysiological and behavioral development).
Keaton Stagaman, Alexandra Alexiev, Michael J. Sieler, Austin Hammer, Kristin D. Kasschau, Lisa Truong, Robyn L. Tanguay, Thomas J. Sharpton   +7 more
doaj   +1 more source

Exposure to Household Air Pollution from Biomass-Burning Cookstoves and HbA1c and Diabetic Status Among Honduran Women [PDF]

, 2018
Household air pollution from biomass cookstoves is estimated to be responsible for more than two and a half million premature deaths annually, primarily in low and middle‐income countries where cardiometabolic disorders, such as Type II Diabetes, are ...
Africano, S., Bachand, A. M., Benka-Coker, Megan L., Brook, R. D., Clark, M. L., Good, N., Koehler, K., L\u27Orange, C., Nelson, T. L., Osorto Pinel, A. B., Peel, J. L., Rajkumar, S., Reynolds, S. J., Volckens, J., Young, B. N.   +14 more
core   +1 more source

Exposure to STEM: Diversity in Maritime Transportation

, 2019
Although the 1954 U.S. Supreme Court decision in the case of Brown vs. Board of Education declared state laws establishing segregated public schools unconstitutional, in 1957 Arkansas Governor Orval Faubus tried to prevent nine African American students from attending school at Little Rock Central High School (LRCHS). Faubus’ attempt to block access to
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

An Empirical Evaluation Of Social Influence Metrics

, 2016
Predicting when an individual will adopt a new behavior is an important problem in application domains such as marketing and public health. This paper examines the perfor- mance of a wide variety of social network based measurements proposed in the ...
Aleali, Ashkan, Guo, Ruocheng, Kumar, Nikhil, Shakarian, Paulo   +3 more
core   +1 more source