Results 111 to 120 of about 4,930,320 (325)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Travelling together alone and alone together: mobility and potential exposure to diversity

, 2017
Quantity and quality of social relations correlate with our happiness and physical health. Our (feeling of) connectedness also matters for the efficacy and functioning of communities and societies as a whole.
Marco te Brömmelstroet, Anna Nikolaeva, Meredith Glaser, M. S. Nicolaisen, C. Chan   +4 more
semanticscholar   +1 more source

Development of the Chick Microbiome: How Early Exposure Influences Future Microbial Diversity

Frontiers in Veterinary Science, 2016
The concept of improving animal health through improved gut health has existed in food animal production for decades; however, only recently have we had the tools to identify microbes in the intestine associated with improved performance.
C. Yeoman, B. Oakley, M. Koci, Ballou Al, Ali Ra, Mendoza Ma, Ellis Jc, Hassan Hm, Croom Wj, Koci Md, A. Ballou, R. Ali, Mary Mendoza, J. C. Ellis, H. Hassan, W. J. Croom   +15 more
semanticscholar   +1 more source

Exposure Diversity

, 2018
The digital environment has fundamentally changed the conditions for media diversity and for exposure diversity in particular, and has made research in this area more important than ever. Paradoxically, the digital information environment, with its abundance of information, has greatly expanded, and at the same time decreased the opportunities for ...
Helberger, N., Wojcieszak, M.
openaire   +2 more sources

Microbial exposure and diversity in Norwegian shrimp processing plants

Journal of Occupational and Environmental Hygiene
Seafood processing workers have a high prevalence of respiratory symptoms and occupational asthma, primarily attributed to allergenic protein exposure. However, exposure to airborne microorganisms from raw materials can also contribute to allergic sensitization and other respiratory ailments.
Fikirte Debebe Zegeye, Anne Straumfors, Peng Lei, Pål Graff, Johanna Samulin Erdem, Anani Komlavi Afanou   +5 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Analysis of effect of nicotine on microbial community structure in sediment using PCR-DGGE fingerprinting

Water Science and Engineering, 2015
Solid or liquid waste containing a high concentration of nicotine can pollute sediment in rivers and lakes, and may destroy the ecological balance if it is directly discharged into the environment without any treatment.
Ai-dong Ruan, Chen-xiao Liu
doaj   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods

Microbiology Spectrum
This study investigated the longitudinal effects of acute (7-day) and prolonged (3-month) high-altitude exposure on gut microbiota in healthy adult males, addressing the limited data available in human populations. A cohort of 406 healthy adult males was
Xianzong Ma, Changwei Duan, Xiaoying Wang, Yurong Tao, Lang Yang, Yongsheng Teng, Yuanming Pan, Mingjie Zhang, Junfeng Xu, Jianqiu Sheng, Xin Wang, Peng Jin   +11 more
doaj   +1 more source

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

Journal of Immunology, 2018
With age, the immune system becomes less effective, causing increased susceptibility to infection. Chronic CMV infection further impairs immune function and is associated with increased mortality in the elderly.
P. Lindau, Rithun Mukherjee, Miriam V. Gutschow, M. Vignali, E. Warren, S. Riddell, K. Makar, C. Turtle, H. Robins   +8 more
semanticscholar   +1 more source