Results 41 to 50 of about 73,466 (119)
A response to ‘Quantifying phenotypic plasticity at multiple levels—A comment on Gómez et al.’
Read the free Plain Language Summary for this article on the Journal blog. Abstract In this reply, we clarify several conceptual misunderstandings raised in response to our Perspective on quantifying phenotypic plasticity. We emphasize that our central argument concerns the rigorous estimation of the magnitude of plasticity, rather than its mere ...
José M. Gómez +3 more
wiley +1 more source
TISSUE EXPRESION OF THE GENES MUTYH AND OGG1 IN PATIENTS WITH SPORADIC COLORECTAL CANCER
Background: MTUYH and OGG1 genes have importance in the base excision repair systems of oxidized DNA bases. Modification of the tissue expression of these genes is related to the increased risk of developing colorectal cancer. Aim: To evaluate the tissue
Enzo Fabrício Ribeiro Nascimento +6 more
semanticscholar +1 more source
ABSTRACT We trace the shift from a nascent to a mature policy subsystem by examining a hitherto overlooked aspect in policy process scholarship: the relationship between advocacy coalition beliefs and the narratives they express over time. The empirical focus of this case study is Sweden's Preventing and Countering Violent Extremism (P/CVE) policies ...
Simone Grännsjö +3 more
wiley +1 more source
A New Local Perimeter Control Approach to Minimum Length Scale in Topology Optimization
ABSTRACT This work presents a novel framework for enforcing minimum length‐scale constraints in topology optimization, a fundamental challenge for ensuring manufacturable designs. Two complementary methodologies are proposed. The first, and primary, approach is based on local perimeter control, which regulates the amount of perimeter within localized ...
Jose A. Postigo +3 more
wiley +1 more source
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu +13 more
wiley +1 more source
A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin +7 more
wiley +1 more source
Ageing causes actin cytoskeleton disorganization, a reduction in cellular components associated with the actin cytoskeleton and focal adhesions, and a reduction in skin firmness. Galactomyces ferment filtrate boosts actin stability, increases expression of anchoring junction proteins, including focal adhesions and protects against loss of firmness ...
Steph Crabtree +12 more
wiley +1 more source
“The Benefits Far Outweigh the Challenges”: Examining Practices of Queer Shared Households in Canada
ABSTRACT This paper focuses on the experiences and practices of LGBTQ+ adults in Canada living in shared housing arrangements. Drawing on qualitative focus group data from eight participants aged 32–67 in three Canadian cities, we identify and discuss three key themes that characterize these arrangements: (a) the material drivers and impacts of shared ...
Celeste Pang +4 more
wiley +1 more source
Aluminum is known to exert neurotoxic effects associated with various neurodegenerative disorders, including Alzheimer's disease (AD). Ibuprofen is a well-known non-steroidal anti-inflammatory drug, which has demonstrated potential efficacy in the ...
Anum Jamil, Aamra Mahboob, T. Ahmed
semanticscholar +1 more source

