Results 111 to 120 of about 6,972,561 (305)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Gene expression profiling in DLBCL primary clinical samples

, 2016
Accession Number: GSE74266 Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array Organism: Homo sapiens Published on 2016-10-05 Summary: Gene expression profiling was performed for 28 DLBCL primary clinical samples and assignment
Aalborg University Hospital, Dybkær, Karen; id_orcid, The Faculty of Engineering and Science (ENG), Klinik Kirurgi og Kræftbehandling, Department of Clinical Medicine, Schmitz, Alexander, Ettrup, Marianne Schmidt, Bilgrau, Anders Ellern, Klinik Diagnostik, Klinik Medicin, Bøgsted, Martin; id_orcid, Jørgensen, Laura Krogh, The Faculty of Medicine, Ranjbar, Benyamin, Aarhus University, Johnsen, Hans Erik, Primo, Maria Nascimento, Marques, Sara Correia, Department of Pathology, Blodsygdomme (Hæmatologi) [Klinik Medicin], Falgreen, Steffen, Laursen, Maria Bach, Bødker, Julie Støve; id_orcid, Mikkelsen, Jacob Giehm, Aalborg University, Department of Mathematical Sciences   +25 more
core  

Gene Expression Modifications by Temperature-Toxicants Interactions in Caenorhabditis elegans

, 2011
Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses.
Vinuela Rodriguez, A., Kammenga Jan E., Joost A. G. Riksen, Riksen Joost A. G., Ana Viñuela, L Basten Snoek, Viñuela Ana, Jan E. Kammenga, Joost A G Riksen, Kammenga, J.E., Snoek, L.B., L. Basten Snoek, Jan E Kammenga, Snoek L. Basten, Riksen, J.A.G.   +14 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Freedom of expression, the double-edged sword

openThis thesis explores how freedom of expression, traditionally a cornerstone of Western democracies, is increasingly instrumentalized by politicians and corporations for their own interests.
LOZANO ARIZA, DANIEL
core  

RNAseq expression analysis of FACS-sorted macrophages from cxcr3.2 mutant and wt zebrafish larvae

, 2021
RNAseq expression analysis of FACS-sorted macrophages from cxcr3.2 mutant and wt zebrafish ...
Willemse, Joost, Torraca, Vincenzo, Sommer, Frida, Meijer, Annemarie H, In 't Veld, Aliede E   +4 more
core  

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Nature Communications, 2017
The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading ...
Ido Goldstein, Ville Paakinaho, Songjoon Baek, Myong-Hee Sung, Gordon L. Hager   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Gene expression analysis in breast cancer [PDF]

, 2010
Breast cancer is the most common type of cancer among females, both in incidence and death. As meaningful biological understanding of the disease is confounded by the existence of various molecular groups and sub-groups, the challenge for targeted drug ...
Mehta, Jai Prakash
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source