Results 11 to 20 of about 12,358,530 (296)

Expression quantitative trait loci are highly sensitive to cellular differentiation state [PDF]

, 2009
Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown.
A Gerrits, Albertina Ausema, Alice Gerrits, AR Whiteley, B Wang, Bert Dontje, Bruno M. Tesson, D Bryder, E Petretto, EC Forsberg, EE Schadt, EE Schadt, EJ Chesler, EJ Chesler, Ellen Weersing, G Dennis Jr, Gerald de Haan, Greg Gibson, HH Goring, J Wang, JD Storey, JJ Keurentjes, JL Peirce, JY Wu, KH Wang, L Bystrykh, Leonid V. Bystrykh, M Morley, MA West, MJ Anderson, MJ Kiel, MV Rockman, N Hubner, NB Ivanova, R Alberts, R Breitling, Rainer Breitling, RC Jansen, Ritsert C. Jansen, SA Monks, SM Chambers, V Emilsson, Xusheng Wang, Y Chen, Y Katoh, Y Li, Y Li, Y Liang, Yang Li   +48 more
core   +12 more sources

GC content of vertebrate exome landscapes reveal areas of accelerated protein evolution

BMC Evolutionary Biology, 2019
Background Rapid accumulation of vertebrate genome sequences render comparative genomics a powerful approach to study macro-evolutionary events. The assessment of phylogenic relationships between species routinely depends on the analysis of sequence ...
R. Huttener, L. Thorrez, T. in’t Veld, M. Granvik, L. Snoeck, L. Van Lommel, F. Schuit   +6 more
doaj   +1 more source

Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly, Aki Endo, Alejandro Brenes, Marek Gierlinski, Vackar Afzal, Andrea Pawellek, Angus I. Lamond   +6 more
doaj   +1 more source

Expression and the Unconscious [PDF]

Frontiers in Psychology, 2017
In the present essay, we aim to develop an expressivist reading of the phenomenon of first-person authority and the adverbial meaning of unconsciousness. In the first part, Wittgenstein's grammatical remarks on the asymmetry between the first -and third-persons in psychological self-ascriptions are developed as an alternative to detectivist ...
Feyaerts, Jasper, Vanheule, Stijn
openaire   +4 more sources

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Nature Communications, 2020
ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma   +11 more
doaj   +1 more source

Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing [PDF]

PeerJ, 2013
Exosomes are nanosized (30–100 nm) membrane vesicles secreted by most cell types. Exosomes have been found to contain various RNA species including miRNA, mRNA and long non-protein coding RNAs. A number of cancer cells produce elevated levels of exosomes.
Piroon Jenjaroenpun, Yuliya Kremenska, Vrundha M. Nair, Maksym Kremenskoy, Baby Joseph, Igor V. Kurochkin   +5 more
doaj   +2 more sources

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

Nature Communications, 2016
Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be ...
Ignacio Sancho-Martinez, Emmanuel Nivet, Yun Xia, Tomoaki Hishida, Aitor Aguirre, Alejandro Ocampo, Li Ma, Robert Morey, Marie N. Krause, Andreas Zembrzycki, Olaf Ansorge, Eric Vazquez-Ferrer, Ilir Dubova, Pradeep Reddy, David Lam, Yuriko Hishida, Min-Zu Wu, Concepcion Rodriguez Esteban, Dennis O’Leary, Geoffrey M. Wahl, Inder M. Verma, Louise C. Laurent, Juan Carlos Izpisua Belmonte   +22 more
doaj   +1 more source

Validez y fiabilidad de un cuestionario sobre la percepción del profesorado de Educación Primaria y Secundaria de la enseñanza en un modelo de currículo basado en competencias

Journal of New Approaches in Educational Research, 2018
El objetivo de este trabajo es desarrollar una escala para conocer la percepción de los docentes de Educación Primaria y Secundaria del modelo de currículo basado en competencias en España.
Luis Miguel García-López, David Gutiérrez, Juan Carlos Pastor, Vicente Romo   +3 more
doaj   +1 more source

Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. [PDF]

, 2016
BackgroundHyperactivation of STAT3 via constitutive phosphorylation of tyrosine 705 (Y705) is common in most human cancers, including head and neck squamous carcinoma (HNSCC).
Gooding, William E, Grandis, Jennifer R, Johnson, Daniel E, Lui, Vivian WY, Pendleton, Kelsey, Peyser, Noah D   +5 more
core   +3 more sources

Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling

Nature Communications, 2021
Long-range looping of an enhancer to a promoter (E-P looping) is a key feature of gene activation; thus, regulation of E-P looping could serve as an effective strategy to precisely control gene expression.
Dahong Chen, Catherine E. McManus, Behram Radmanesh, Leah H. Matzat, Elissa P. Lei   +4 more
doaj   +1 more source