Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Towards a New Virtualist Design Research Programme
This paper considers how the influence of computer-cyber networks informs a new way of seeing on the part of designers as well as design researchers. In an adaptation of the notion of “virtual realities” made possible by computer technology, this new ...
David Wang
doaj +1 more source
Anti-Adjacency Matrices of Certain Graphs Derived from Some Graph Operations
If we go through the literature, one can find many matrices that are derived for a given simple graph. The one among them is the anti-adjacency matrix which is given as follows; The anti-adjacency matrix of a simple undirected graph $G$ with vertex set
Manju V N, Athul T B, Suresh Singh G
doaj +1 more source
On the expressiveness and decidability of higher-order process calculi [PDF]
AbstractIn higher-order process calculi, the values exchanged in communications may contain processes. A core calculus of higher-order concurrency is studied; it has only the operators necessary to express higher-order communications: input prefix, process output, and parallel composition.
LANESE, IVAN+3 more
openaire +10 more sources
The Influence of Emotion Expression on Perceptions of Trustworthiness in Negotiation [PDF]
When interacting with computer agents, people make inferences about various characteristics of these agents, such as their reliability and trustworthiness.
Antos, Dimitrios+3 more
core +4 more sources
Regular Expressions in a CS Formal Languages Course
Regular expressions in an Automata Theory and Formal Languages course are mostly treated as a theoretical topic. That is, to some degree their mathematical properties and their role to describe languages is discussed.
Morazán, Marco T.
core +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr+4 more
wiley +1 more source
OSG-GEM: Gene Expression Matrix Construction Using the Open Science Grid
High-throughput DNA sequencing technology has revolutionized the study of gene expression while introducing significant computational challenges for biologists.
William L. Poehlman+4 more
doaj +1 more source
Bricklayer: Elementary Students Learn Math through Programming and Art [PDF]
As computer science becomes more prevalent in the K-12 world, elementary schools are increasingly adopting computing curricula. Computer scientists have recognized the connection between math and computer science, but little work has demonstrated how and
Friend, Michelle
core +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten+10 more
wiley +1 more source