Results 71 to 80 of about 2,116,656 (327)

Method for quantitative expression of psychological safety and security distance (PSSD) using fuzzy theory

open access: yesEmergency Management Science and Technology, 2022
Usually psychological safety and security distance (PSSD) is difficult to express quantitatively as it belongs to the field of social science. This article presents a mathematical approach for the PSSD expression using fuzzy theory.
Chao Wu, Chen Liu, Liangguo Kang
doaj   +1 more source

Expressiveness of Metric modalities for continuous time [PDF]

open access: yesLogical Methods in Computer Science, Volume 3, Issue 1 (February 23, 2007) lmcs:2225, 2006
We prove a conjecture by A. Pnueli and strengthen it showing a sequence of "counting modalities" none of which is expressible in the temporal logic generated by the previous modalities, over the real line, or over the positive reals. Moreover, there is no finite temporal logic that can express all of them over the real line, so that no finite metric ...
arxiv   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

A Variant of the Growing Neural Gas Algorithm for the Design of an Electric Vehicle Charger Network

open access: yesMathematics
The Growing Neural Gas (GNG) algorithm constitutes an incremental neural network model based on the idea of a Self-Organizing Map (SOM), that is, unsupervised learning algorithms that reduce the dimensionality of datasets by locating similar samples ...
Manuel Curado   +4 more
doaj   +1 more source

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Hierarchical Multi-Bottleneck Classification Method And Its Application to DNA Microarray Expression Data [PDF]

open access: yes, 2003
The recent development of DNA microarray technology is creating a wealth of gene expression data. Typically these datasets have high dimensionality and a lot of varieties.
Hsu, Wen Jing   +2 more
core  

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Home - About - Disclaimer - Privacy