Results 71 to 80 of about 1,656,664 (330)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Learning Causal Biological Networks With the Principle of Mendelian Randomization
Frontiers in Genetics, 2019 Although large amounts of genomic data are available, it remains a challenge to reliably infer causal (i. e., regulatory) relationships among molecular phenotypes (such as gene expression), especially when multiple phenotypes are involved.
Md. Bahadur Badsha, Audrey Qiuyan Fu
doaj +1 more source
, 2013 One of the central questions in free speech jurisprudence is what activities the First Amendment encompasses. This Article considers that question in the context of an area of increasing importance – algorithm-based decisions.
Bolin, Malin, Nordin, Maria
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Sex chromosome evolution in parasitic nematodes of humans
Nature Communications, 2020 Many nematode worms, including Caenorhabditis elegans have XX/XO sex determination, while other species have XY. The authors use a new genome assembly of the filarial parasite Brugia malayi and published data to show that nematode sex chromosome ...
Jeremy M. Foster +22 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
BMC Bioinformatics, 2005 The MCBIOS 2004 conference brought together regional researchers and students in biology, computer science and bioinformatics on October 7th-9th 2004 to present their latest work.
Slikker William, Wren Jonathan D
doaj +1 more source
Nature and Science of Sleep, 2022 Papangkorn Inkeaw,1 Pimwarat Srikummoon,2,3 Jeerayut Chaijaruwanich,1,4 Patrinee Traisathit,2,3,5 Suphakit Awiphan,1,4 Juthamas Inchai,6 Ratirat Worasuthaneewan,7 Theerakorn Theerakittikul6,7 1Data Science Research Center, Department of Computer Science,
Inkeaw P +7 more
doaj
Computational identification of protein-coding sequences by comparative analysis [PDF]
International Journal of Data Mining and Bioinformatics, 2007 Gene prediction is an essential step in understanding the genome of a species once it has been sequenced. For that, a promising direction in current research on gene finding is a comparative genomics approach. In this paper, we present a novel approach to identifying evolutionarily conserved protein-coding sequences in genomes.
Wu, Feihong +3 more
openaire +18 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source