Results 51 to 60 of about 327,732 (266)
ENHANCED HETEROLOGOUS EXPRESSION IN E.COLI
Studia Universitatis Babes-Bolyai Chemia, 2019 Apoptotic regulation has been implicated in many human diseases, including cancer, autoimmune disease, inflammation and neuro degradation. Mapping up critical apoptosis regulators is a strategy for the development of new therapies [1, 2].
Katalin NAGY +5 more
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ICOR: improving codon optimization with recurrent neural networks
BMC Bioinformatics, 2023 Background In protein sequences—as there are 61 sense codons but only 20 standard amino acids—most amino acids are encoded by more than one codon.
Rishab Jain +4 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Applied SciencesAs global aging rises, identifying strategies to mitigate age-related physical decline has become an urgent priority. Dance represents a promising exercise modality for older adults, yet few studies have quantified the external loads older dancers ...
Tyrone M. Loría-Calderón +4 more
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Codon optimization with deep learning to enhance protein expression
Scientific Reports, 2020 Heterologous expression is the main approach for recombinant protein production ingenetic synthesis, for which codon optimization is necessary. The existing optimization methods are based on biological indexes.
Hongguang Fu +8 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Optimization of Expression Matching for String Matching
Dianxin kexue, 2013 As the requirement of network security application increases, more and more redundant patterns appear and the patterns' amount of intrusion detection system（IDS）raises.
Tianlong Yang, Hongli Zhang
doaj +2 more sources
Soluble expression of recombinant cyclophilin A in Escherichia coli
浙江大学学报. 农业与生命科学版, 2010 To produce a large amount of soluble cyclophilin A (CypA) protein, the recombinant pRSET -CypA plasmid was transferred into E. coli BL21. Using the 2×YT culture medium, the medium compositions of carbon source, nitrogen source and ampicillin ...
YAN Xiao +3 more
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Frontiers in Microbiology, 2018 Increasing the final titer of a multi-gene metabolic pathway can be viewed as a multivariate optimization problem. While numerous multivariate optimization algorithms exist, few are specifically designed to accommodate the constraints posed by genetic ...
Stephen C. Heinsch +5 more
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