Results 81 to 90 of about 6,393,379 (315)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Plants, 2020 Stress-associated proteins (SAPs) are a class of zinc finger proteins that confer tolerance to a variety of abiotic and biotic stresses in diverse plant species.
Wei Lai +7 more
doaj +1 more source
Gene expression profile of pulpitis [PDF]
Genes & Immunity, 2016 The cost, prevalence and pain associated with endodontic disease necessitate an understanding of the fundamental molecular aspects of its pathogenesis. This study was aimed to identify the genetic contributors to pulpal pain and inflammation. Inflamed pulps were collected from patients diagnosed with irreversible pulpitis (n=20).
Galicia, Johnah C. +3 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Expression profile of sequenced reads in four libraries.
, 2013 Expression profile of sequenced reads in four libraries.
Tao Chen (75911) +5 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Gene expression profile of VIN lesions in comparison to controls
, 2006 Accession Number: GSE5563 Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array Organism: Homo sapiens Published on 2006-11-01 Summary: In order to understand the molecular mechanism behind Vulvar Intraepithelial Neoplasia (VIN),
Santegoets, Lindy A M. +3 more
core +1 more source
miRNA expression profile by SLRT-PCR and cluster analysis.
, 2012 A: Model of miRNA expression pattern. B: Heatmap of miRNA expression profile. The cluster was done on the basis of log2 (expression level in treatment/expression level in control). Yellow shows down-regulation. Blue shows up-regulation.
Lifang Zhang (130786) +4 more
core +1 more source