Results 101 to 110 of about 238,886 (292)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Talk the Walk: Walking as a Field Method in Natural History, Urban Studies, and Conservation Science

Humans
Perhaps one of the most defining ‘techniques of the body’ for human beings is bi-pedal walking. This study brings together studies in socio-cultural anthropology to reflect on the nature of walking as a field method in different social-environmental ...
Lav Kanoi, Yufang Gao, Michael R. Dove
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Aesthetic Treatment of Scenography for the Theatrical Script “Womenfolk (Al Walaya)” An Analytical Applied Study

Journal of Architecture, Art & Humanistic Science
theatrical production includes a set of interrelated elements that complement each other in a complex process aimed at achieving the message of the play and communicating it to the audience. This research examines the aesthetic elements of the theatrical
Assist.Prof. Dr. Dalia Saleh Abdel Wahab Farah
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

PERILAKU TINDAK TUTUR USTAD DALAM PENGAJIAN: KAJIAN SOSIOPRAGMATIK DENGAN PENDEKATAN BILINGUAL

Jurnal Penelitian Humaniora, 2013
In general, the purpose of this study is to describe the illocutionary speech act of chap- lain using bilingual approach. This is a qualitative research. The data are in the form of speech collected from recordings of cleric K.H.
Rini Indah Sulistyowati, Harun Joko Prayitno, Yakub Nasucha   +2 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Cultural Influence of the Odabara Dance on the Cultural Development of Ikem Community, Isi-Uzo Local Government, Enugu State

Accelerando: BJMD
The sociocultural impact of the Odabara dance on the evolution of culture in the Ikem community, Isi-Uzo Local Government Area of Enugu State, is examined in this paper. The dance, which dates back to 1975, is analyzed in terms of historical influences,
Emmanuel Oyeunji Alemede, Akinbiola Oluwabusayo   +1 more
doaj  

Actualization of stylistically charged of phraseological units in poetry of V. Vysotsky

Неофилология, 2015
It is devoted to studies of the specifics of stylistically marked phraseological units functioning in the works by V.S. Vysotsky. V.S. Vysotsky’s idiostyle is characterized by the use of stable reproducible combinations – set phrases, aphorisms, sayings,
Luiza Ravshanovna SIDORKOVA
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source