Results 131 to 140 of about 7,954 (252)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

How are the youth? A brief-longitudinal study on symptoms, alexithymia and expressive suppression among Italian adolescents during COVID-19 pandemic. [PDF]

Int J Psychol, 2022
Pace CS, Rogier G, Muzi S.
europepmc   +1 more source

To Suppress or Not to Suppress: Toward a More Comprehensive Understanding of Expressive Suppression

Expressive suppression (ES), an emotion regulation strategy used to inhibit emotional expressions, is a functional skill that is used throughout individuals’ daily lives to manage emotional and social experiences. The ES process requires effort, which is likely applied based on circumstance variations (e.g., type and intensity of emotions, social ...
openaire   +1 more source

Expression of semaphorin 3E is suppressed in severe asthma [PDF]

Journal of Allergy and Clinical Immunology, 2017
Hesam Movassagh, Lianyu Shan, Jamila Chakir, John F. McConville, Andrew J. Halayko, Latifa Koussih, Abdelilah S. Gounni   +6 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Expressive suppression to pain in others reduces negative emotion but not vicarious pain in the observer. [PDF]

Cogn Affect Behav Neurosci, 2021
Anderson SR, Li W, Han S, Reynolds Losin EA.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

How Physical Exercise Reduces Problematic Mobile Phone Use in Adolescents: The Roles of Expression Suppression, Depression, Anxiety, and Resilience

Psychology Research and Behavior Management
Fa Ji,1,2 Qilong Sun,3 Wei Han,3 Yansong Li,1 Xue Xia4,5 1School of Physical Education, Qingdao University, Qingdao, People’s Republic of China; 2Development Center for Water Sports, Qingdao University, Qingdao, People’s Republic of China; 3Liaocheng ...
Ji F, Sun Q, Han W, Li Y, Xia X
doaj  

The Roles of Happiness Motives in Cognitive Reappraisal and Expressive Suppression: A Longitudinal Study in Emerging Adults. [PDF]

Behav Sci (Basel)
Li W, Yang K, Kong F.
europepmc   +1 more source